Basic Drug Info

Manufacturer:

Ranbaxy Laboratories Ltd.

Active Substance:

Prednisone

Drug Form:

Film-coated tablets, injection fluids, ointment

Available Doses:

Tablets: 5 mg, 10 mg, 20 mg; Injection: 40 mg

Product

Price Per pill Order

Orapred Dispersible.2.5mg x 30 tablet

€25.87€0.86Buy

Orapred Dispersible.2.5mg x 60 tablet

€44.53€0.74Buy

Orapred Dispersible.2.5mg x 90 tablet

€62.15€0.69Buy

Orapred Dispersible.2.5mg x 120 tablet

€75.63€0.63Buy

Orapred Dispersible.2.5mg x 180 tablet

€83.92€0.47Buy

Product

Price Per pill Order

Orapred Dispersible.5mg x 60 tablet

€46.60€0.78Buy

Orapred Dispersible.5mg x 90 tablet

€62.15€0.69Buy

Orapred Dispersible.5mg x 120 tablet

€72.52€0.60Buy

Orapred Dispersible.5mg x 180 tablet

€88.07€0.49Buy

Product

Price Per pill Order

Orapred Dispersible.10mg x 60 tablet

€51.78€0.86Buy

Orapred Dispersible.10mg x 90 tablet

€67.33€0.75Buy

Orapred Dispersible.10mg x 120 tablet

€77.70€0.65Buy

Orapred Dispersible.10mg x 180 tablet

€93.25€0.52Buy

Product

Price Per pill Order

Orapred Dispersible.20mg x 60 tablet

€54.89€0.91Buy

Orapred Dispersible.20mg x 90 tablet

€70.44€0.78Buy

Orapred Dispersible.20mg x 120 tablet

€79.77€0.66Buy

Orapred Dispersible.20mg x 180 tablet

€96.36€0.54Buy

Product

Price Per pill Order

Orapred Dispersible.40mg x 60 tablet

€56.97€0.95Buy

Orapred Dispersible.40mg x 90 tablet

€72.52€0.81Buy

Orapred Dispersible.40mg x 120 tablet

€81.85€0.68Buy

Orapred Dispersible.40mg x 180 tablet

€98.43€0.55Buy

What is Prednisolone?

Prednisolone is a corticosteroid drug used in the treatment of patients with moderate to severe rheumatoid arthritis (RA). The rationale for the use of corticosteroids in RA is the rapid control of symptoms during the phases of exacerbation of the disease mediated by the anti-inflammatory effect.

arthritis

In addition to simple symptomatic improvement, corticosteroids have been shown to slow down the rate of destruction of the joints at the same like the disease-modifying antimicrobial drugs (DMARD). In current treatment strategies for less aggressive forms of AR, corticosteroids are often associated with a DMARD (usually the methotrexate that is better tolerated). Systemic side effects, even at low doses, are the main limiting factor for their long-term use. Prednisone, at a dose of 7.5 mg a day, is able to maintain good control of symptoms (which at this dose lasts only 6-12 months) and to slow the progression of joint damage to a maximum of 2-4 years without problems, after which it must be gradually reduced and suspended.

Prednisone, administered in the form of an immediate-release oral preparation, is absorbed rapidly and almost completely; reaches maximum plasma concentrations after approximately 2 hours. More than 80% of prednisone is converted into the active metabolite prednisolone via hepatic first pass metabolism. After new hepatic metabolism, prednisolone is transformed into inactive metabolites that are mainly eliminated via the kidneys. The half-life of prednisolone is about 3 hours. The profile of plasma concentrations of prednisone MRI is very similar to that of immediate-release prednisone (at the same dose) with the difference of a time to reaching delayed peak levels of about 4 hours.

MRI prednisone tablets should be taken whole around 10pm, not in the morning as is currently the case with traditional preparations. If more than 2-3 hours have passed since the evening meal, the CPR recommends taking them after a snack (eg a slice of bread with ham or cheese); fasting may reduce bioavailability.

What is Prednisolone used for?

Prednisolone is mainly used in anti-inflammatory and antiallergic therapy, in case of asthma or inflammation (arthritis). They are also used for Addison’s disease (chronic adrenocortical insufficiency characterized by hyperpigmentation, sense of weakness, weight loss, in these subjects even trivial infectious or traumatic stimuli can lead to shock), for the prevention of rejection syndrome (after transplantation of ‘organ, due to their immunosuppressive effect) and in various types of blood and skin diseases.

Like all NSAIDs, corticosteroids can also cause damage to the gastric mucosa, both by direct action and by interference with the metabolism of arachidonic acid and by decreasing the number of prostaglandins, which have a mucoprotective effect.

Other undesirable effects are:

  • redistribution of body fat towards the face and neck and muscle thinning (Cushing’s syndrome)
  • osteoporosis
  • hyperglycemia (undesirable in diabetics) and decreased resistance to infections, which can lead to states such as oral candidiasis
  • increase in wound healing time
  • appearance or worsening of acne
  • hirsutism effects.

They may also have mineralocorticoid effects (sodium and water retention due to aldosterone receptors binding) and blood clotting effects.

What is the difference between Prednisone and Prednisolone?

Both Prednisone and Prednisolone belong to the same class of medications called synthetic corticosteroids and are used for the treatment of the same conditions, namely ulcerative colitis and other gastro-intestinal diseases of inflammatory nature, rheumatoid diseases, airway inflammations, such as bronchitis, asthma and associated problems, etc.

Prednisone and Prednisolone are interchangeable drugs, but according to this study, the levels of Prednisolone are cleared faster and in a safer way in patients with compromised liver function, therefore its use is preferable in individuals from this subcategory.

What are the side effects of Prednisolone?

In the 3-month comparison study , there were no differences between immediate-release prednisone and MR prednisone in safety profile, but a predefined list with standardized score was not used for recording adverse events as would have been necessary. In the open-label extension study, with a median duration of treatment of 281 days and a mean prednisone dose of 6.8 mg per day, the incidence of adverse events was 51% (including a 4.8 % drop out), similar to that of historical controls.

During the 12 months of observation required by the controlled study and by the open-label extension phase, the corticotropin release hormone (CRH) response test performed in three steps several (at the baseline, at the end of the 3 months in double blind and 9 months in the open) on a small group of patients (n = 28) did not find signs of suppression of the pituitary-adrenal axis.

Precautions

A single dose of cortisonic, even very high, is practically devoid of toxic effects, which occur with the chronicity of the use of the drug. The main problem that can lead to prolonged use of these drugs is adrenal insufficiency, which can also become fatal.

Contraindications

synthetic-glucocorticoid

Prolonged therapy should be interrupted gradually; corticosteroids are contraindicated in cases of:

  • ulcer
  • diabetes
  • heart failure
  • osteoporosis
  • hypertension

Where can you buy Prednisolone online?

side-effects-of-Mobic

Prednisolone is a generic version of more expensive brand medications containing the same active component. Generic drugs are easily available online, but caution should be exercised when ordering healthcare products. Find a vendor with clearly formulated terms and conditions of use, as well as protected customer privacy and secure payment. A good online pharmacy makes buyer’s health its priority, so look for e-drugstores where healthcare services are included or offered as an option.

One can buy Prednisolone online and have it delivered to a specified address. This convenience does not exempt you from your responsibility as a patient: you need to be aware of existing contraindications and possible pharmacological interactions to avoid. Medical consultation is required under all circumstances.

What are other names for Prednisolone?

  • Aripride – Sarian Healthcare
  • Depotex – German Remedies (Aeroforce)
  • Emcort – Captab Biotec
  • Intralone – Intra Labs India Pvt. Ltd.
  • Lumi-M – Aronex Lifesciences Pvt. Ltd.
  • Macpred – Macleods Pharmaceuticals Ltd. (Macphar)
  • Nicort – AHPL
  • Paxopred – Pax Healthcare
  • Predace – Micro Labs Ltd (Gratia)
  • Predon-M – Orion Biotech Pvt. Ltd.
  • Predzest Tablet – Innovative Pharmaceuticals
  • Predzen Tablet – Ikon Remedies Pvt. Ltd.
  • Premisol – Molekule India Pvt. Ltd.
  • Zencort-M – Zenon Healthcare Ltd

(4 voices, average: 5 of 5) 28241 views

Customer reviews

By Thad,

Friday 22nd of November 2019

Does prednisone as an antihistamine cause irritating side effects like heartburn? Thanks for the reply

By James Daniels M.D,

Monday 25th of November 2019

All corticosteroids, which are a class of drugs other than antihistamines, have the side effect of gastritis and, in the case of therapies with high doses of cortisone or prolonged, it is a good practice to take gastroprotectors. Antihistamines do not generally cause stomach discomfort.

By Irish,

Tuesday 17th of December 2019

Hi, my 7-year-old son was diagnosed with autoimmune thrombocytopenia; he was hospitalized for a month and as a therapy he was given immunoglobulins but to no avail. From September 14th he takes prednisone as a drug and now the platelets, which had previously only fallen to 1000, have reached 111,000; the daily dose is 60mg: are there any prospects that we can definitely recover from this disease?

By Dr Kaufman,

Wednesday 18th of December 2019

Good morning. Recovery from autoimmune thrombocytopenia is possible especially in children. At the moment the platelets have a good enough value to protect it from abnormal bleeding even in the case of traumatic events or in the case of surgery, even major surgery. In any case, I advise you to have your child followed by a specialized hospital pediatric hematology division.

By Willard,

Saturday 28th of December 2019

This year I had repetitive coughs and colds, even now I didn’t completely pull out, besides my left ear hurts and if I press the part under the ear too, I also feel pain in the teeth of the lower left part of the mouth, even if the dentist didn’t find me anything. I made two visits to the doctor: both at different times they gave me Prednisone, I did an ultrasound of the part just below the left ear, nothing significant was found. Why do I keep feeling bad?

By Dr Kaufman,

Thursday 2nd of January 2020

The pain may be due to an inflammation of the ear. The diagnosis, in this case, will be possible by visiting your otolaryngologist and a possible audiometric and tympanometric examination. Or it could be an inflammation of the jaw joint, the symptoms of which are pain under the pressure under and in front of the ear, pain in the ear when sharp, chewing, yawning, tightening of the teeth. A specialist will certainly provide an accurate examination of the cervico-facial and oro-rino-pharyngeal area.

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