Basic Drug Info

Manufacturer:

Cipla Ltd.

Active Substance:

Tadalafil citrate, dapoxetine

Drug Form:

Tablet

Available Doses:

tadalafil 20 mg, dapoxetine 60 mg

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What Is Tadapox?

Tadalafil-citrate-dapoxetine

Tadapox is a combinatory drug containing two active substances, tadalafil and dapoxetine, each of them addresses a different issue with men’s sexual health. The drug is used as a first-line symptomatic treatment for erectile dysfunction (ED) and premature ejaculation (PE) and is a unique two-in-one solution.

The drug is taken prior to sexual activity and continues to produce its medicinal effect during the ensuing 36 hours.

Active Substances & Action Mechanism

Tadapox is a male sexual health drug with a dual function. The main difference between Tadapox and other drugs in the Cialis group is quite present. How is Tadapox tadalafil different from Cialis? And why is Tadapox a good alternative to Cialis? Cialis is based on tadalafil as an active component whereas Tadapox consists of two active components – tadalafil and dapoxetine.

The drug is effective for 36 hours. At any time during this period, the patient can perform a sexual act. It is necessary to take the tablets in half an hour before the planned sexual act. It is necessary to take sufficient quantity of water with a tablet.

Active Substance Tadalafil

One of the two active substances contained in Tadapox is tadalafil. This molecule was designed to relax the muscles and blood vessels of the penis, allowing better blood circulation and therefore provides a better contraction of the male.

The efficacy of tadalafil was assessed using a questionnaire on sexual functions before and after taking. Sexual activity, the ability to achieve and maintain penile erection, thus improves 30 to 60 minutes after taking the prescribed dose. Other studies have shown that erection improvement can last up to 36 hours after taking this Cialis equivalent. You can take this pill against impotence several hours before sex while still benefiting from the positive effects of the product.

Tadalafil exerts its action if there is sexual stimulation. No effect is to be declared if the excitation does not take place. The patient can take his dose of Tadalafil without prescription several hours before without having an erection in the pants.

The effectiveness of tadalafil is therefore closely related to the presence of stimulation. If the approach of intercourse is felt in the patient’s body, the erection occurs immediately and naturally, and can be maintained for a long time thanks to this male pill.

In some cases, scientists found a slight delay effect, which prolonged the sexual intercourse longer than usual. In addition, thanks to the long duration of its effectiveness, tadalafil allows you to resume sexual activity just after having sex. In most patients, the effect of tadalafil can be felt for 36 hours.

Active Substance Dapoxetine

premature-ejaculation-dapoxetine

The first drug against premature ejaculation, dapoxetine, will be marketed in early 2013 under the name of Priligy. Already available internationally, this molecule multiplies by three the interval between the beginning of penetration and ejaculation.

The American Psychiatric Reference Manual (DSM-5) defines the disorder as “ejaculation triggered by minimal stimulation before, at or just after penetration, and occurring consistently or recurrently before man wants it” without however, mention the duration of penetration. It is estimated, however, that 90% of men who have it do not take more than one minute after the start of the sexual act, and even less than 30 seconds for 80% of them. In the general population, the median duration is between 5 minutes 30 seconds and 6 minutes. Above all, the vast majority of these men complain of a lack of control of the fateful moment.

Dapoxetine belongs to a family of antidepressants called serotonin reuptake inhibitors, a neurotransmitter found in the brain. Its short duration of action (a few hours) that makes it a bad antidepressant becomes an advantage here. The effect of withdrawal, which occurs when the therapeutic family is stopped too abruptly, is notably less pronounced.

In fact, the main merit of dapoxetine may well be to decomplex men with premature ejaculation, so they dare to talk to a sexologist. Beyond the old methods still proposed to delay the imminence of orgasm (stop movements back and forth, pressure of the glans or the base of the penis), there are now more global approaches that improve the sexuality despite the disorder. It should also be remembered that, in the studies, the majority of premature ejaculatory partners said they were quite satisfied with their sexual relationship. It would be naïve to pretend to reduce sexuality to a matter of ejaculatory control.

Medical Applications

  • to improve the erectile hardness. This effect happens thanks to tadalafil;
  • to treat premature ejaculation – thanks to dapoxetine;
  • to prolong orgasm – thanks to the effect of the combination of two active components.
  • to stabilize erection and avoid flaccidity;
  • increase control over erection;
  • longer duration of sexual intercourse without loss of sensitivity.

After taking a tablet, erection occurs as a result of improved blood circulation. Note that erection only happens under condition of erotic excitement. In the composition of Tadapox, tadalafil keeps erection stable and long-lasting. Dapoxetine prevents premature ejaculation. To be more precise, this moment is delayed, prolonging the IVL (intravaginal latency time) by more than three times. After ejaculation, recharge for a new erection can occur much faster than in an unmedicated state. The possibility of repeating a sexual act is kept thanks to tadalafil.

Dosage & Posology

Tadapox is taken by mouth before sexual contact in 30 minutes at best, and in a minimum of 15-20 minutes before sexual intercourse.

After taking the medicine, you can define the individual reactions of your body to Cialis with dapoxetine. In most cases the drug is completely removed from the body within 36 hours after consumption. For this reason, it is recommended to take Tadapox only once a day.

Warning: it is absolutely not recommended to take Tadapox with alcohol.

Warnings And Precautions

A cardiological and ophthalmological assessment is essential before any prescription in the subjects at risk. In case of renal or hepatic insufficiency and in the elderly, do not exceed the dose of 10mg per dose. Tadapox should be used with caution, in case of anatomical abnormality of the penis, priapism-prone pathologies (polycythemia, sickle cell disease), progressive peptic ulcer. Because of dizziness and reported visual disturbances, patients must know how they react to these molecules before driving or handling machines.

In order to achieve better efficacy of Tadapox, tobacco, alcohol, and narcotic substances should be avoided. Possible psychosocial causes must be identified and treated. Some drugs are deleterious for erectile function, such as thiazide diuretics, neuroleptics and antiandrogens in particular.

The combination of Tadapox with nitrates in all its forms is contraindicated because of a risk of sudden hypotension. The concomitant use alongside with enzyme inhibitors, including antiproteases and antifungals, calcium channel blockers should be avoided.

Tadapox are contraindicated:

  • in subjects for whom sexual activity is inadvisable, with unstable angina, recent myocardial infarction or stroke, severe heart failure.
  • in case of ischemic optic neuropathy, retinitis pigmentosa, hypotension, uncontrolled rhythm disorders.
  • in case of severe hepatic and renal insufficiency.
  • in case of known hypersensitivity to the different products and in the subjects of less than 18 years old.

Tadapox Side Effects

Usually, for medicines containing tadalafil or dapoxetine, side effects can occur in the form of headaches (11% of cases) and dyspepsia (7%). Adverse events of taking tadalafil rarely occur and are of short or medium duration.

A detail to note: even if the side effects are noted, after 4-5 intakes, they weaken and disappear completely. However, if serious side effects occur, stop taking Tadapox and talk to a doctor.

Side effects include myalgia, dorsalgia, hot flashes, stuffy nose. Even more rarely are there ocular problems, swelling of the eyelids, vertigo, hyperemias. It should be noted that the active component (tadalafil) is suitable for subjects who do not show non-reception to other substances used to improve erection. So, if the side effects do not manifest after taking sildenafil (main component of Viagra) or vardenafil (active component of Levitra), chances are that Tadapox will suit you too.

With regard to the active component of dapoxetine, pharmacology offers drugs against premature ejaculation, such as Priligy, and these drugs are based on dapoxetine. So, it’s a way to prolong erection tested by time and pharmacology.

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Customer reviews

By Boris,

Wednesday 4th of December 2019

I have a stable story with a girl that we meet often and without planning. Cialis 5mg, if it worked, would give me more peace of mind from the planning point of view, since taking 10mg every other day I always have to try to make the relationship happen on the day I took the drug.

My questions are the following: 1. are the two doses equally effective?. 2. In the blood I have a higher dose taking 5mg every day or 24 hours after taking 10mg?

By Dr Kaufman,

Thursday 5th of December 2019

Dear User, frankly, I do not see significant differences between the two methods of taking tadalafil, while stressing that the drug does not find its optimization in the assumption of a sexual relationship, but in the long term. At this point, I believe that the synergy between andrologist, psycho-therapist and partner, is the best weapon to rebalance the clinical picture.

By Winfred,

Saturday 28th of December 2019

What contraindications can occur from prolonged intake of Amiodarone? I am a patient who, due to some episodes of arrhythmias (a few years ago), was treated with ablation surgery and hopefully solved by taking Amiodarone to the extent of half a tablet a day, except on Sundays. I ask, given the long duration (it is now 4 years) of taking this drug, if complications or contraindications can occur. In addition, I would like to know if a periodic intake of Tadapox 20mg can cause side effects and, if so, which ones.

By Dr Kaufman,

hursday 2nd of January 2020

Amiodarone has long been considered among the most effective antiarrhythmics; like all pharmacological substances, obviously, taking it for prolonged periods can create problems. Among the cardiovascular side effects we must include sinus bradycardia, which appears in about 10% of patients and is dose-dependent; it can slow down the conduction of the electrical impulse in the sinus-atrial and atrio-ventricular area, up to the block: this effect results in a more or less marked reduction of the ventricular frequency.

Amiodarone, despite being an anti-arrhythmic, can cause arrhythmias, particularly torsional tachycardia, which can be spontaneously exhausted in a few seconds, but which can turn into ventricular fibrillation. Furthermore, one must mention hypotension and heart failure. These cardiovascular effects occur more easily in the presence of electrolyte imbalances (hypokalemia, hypocalcemia and hypomagnesemia) or in the case of simultaneous administration of drugs (especially antiarrhythmics and hypotensive agents). Relatively frequent (20-35% of patients in therapy) the central side effects, that is on the nervous system: in particular tremors, disorders of motility, sleep disorders, headache.

Among the dermatological side effects is photosensitization, which appears months after the start of therapy and is caused by ultraviolet rays A; this effect disappears a few months after stopping therapy. More frequent are the side effects on the thyroid gland, the best known also by patients; Amiodarone acts with a direct toxic mechanism on the thyroid cells and through the release of iodine, causing both hyperthyroidism and hypothyroidism. The effects on the thyroid often become permanent, not reversible, that is, with the suspension of therapy.

At the hepatic level, the haematochemical finding of content increase of transaminases is very frequent; not frequent a real hepatitis from Amiodarone. In the field of hematology, Amiodarone can cause anemia, leukopenia (reduction of white blood cells) and thrombocytopenia (reduction of platelets).

Frequent and known ophthalmic side effects: optic neuropathies, photosensitivity, pigmentation and corneal degeneration (reversible with immediate suspension of therapy).

At pulmonary level, apart from the possibility of coughing, pleural pain, bronchospasm, the most important side effect, due to its seriousness, is pulmonary fibrosis: a condition of imbibition and thickening of the barrier between the alveolus and capillary, which causes difficulties to gas exchange (oxygen and carbon dioxide) then to respiration; fibrosis is not reversible and tends to be evolutionary, ie to worsen.

In conclusion, prolonged therapy requires attention and observation of many objective and subjective elements, on the part of the doctor and the patient; Amiodarone therapy should be considered contraindicated in the presence of pre-existing heart diseases such as severe heart failure with hyperkinetic arrhythmias, marked bradycardias, pre-existing thyroid diseases, chronic liver diseases and chronic and potentially debilitating lung diseases.

Taking Tadapox obviously involves the risk of drug interactions, in particular hypotensive effects (pressure reduction) considering the vasodilation effect exerted by sildenafil; however there is no absolute contraindication, it must be common sense and knowledge of one’s physical condition to guide the patient, and of course a physical examination and supervising healthcare professional’s opinion is required at all times.

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