The following are the drugs most used in therapy against premature ejaculation, and some examples of pharmacological specialties; it is up to the doctor to choose the most suitable active ingredient and posology for the patient, based on the severity of the disease, the health status of the patient and his response to treatment. The neurotransmitter serotonin and its receptors play a central role in the neurological mechanisms that modulate ejaculation. De-regulation of the serotonin concentration or the sensitivity of its receptors in the nervous ejaculatory centers can cause premature ejaculation, hence the drugs used in therapy of PE are related to SSRI class.
Priligy (dapoxetine) is a premature ejaculation (PE) medication administered orally. Up to date, Priligy is the only a delaying pharmacological response, Priligy, a systemic drug administered orally with action in the central nervous system based on dapoxetine, a molecule that belongs to the class of drugs used as antidepressants (SSRI inhibitors, selective serotonin reuptake inhibitors). The drug is taken on demand, which means before a sexual activity is planned.