Filitra

Filitra is based on vardenafil, the third reversible selective phosphodiesterase type 5 inhibitor to have appeared on the market. Phosphodiesterases (PDEs) are a group of enzymes implicated in numerous cellular functions. PDE5 is present in high concentration in the smooth muscle of the corpus cavernosum of the penis where the enzyme promotes the degradation of cyclic guanosine monophosphate (cGMP). The increase in cGMP results in a relaxation of smooth muscle cells: vasodilation, which allows an increase in blood flow in the corpus cavernosum of the penis, is the basis of the mechanism of erection. The physiological mechanism of erection, following sexual stimulation, is mediated by the release of nitric oxide (NO) at the level of the corpora cavernosa by the postsynaptic parasympathetic neurons and, to a more modest extent, by the endothelial cells; Nitric oxide rapidly diffuses and stimulates the guanilate-cyclase in the smooth muscle cells that surround the cavernous sinusoids, increasing the content of cGMP that causes their release1.

The participation of the partner in the sexual act therefore becomes a determining factor. If there is no excitement and emotional involvement, the drug has no effect. Vardenafil does not increase the frequency and intensity of sexual desire. Vardenafil, like sildenafil, has a weak inhibitory activity also against PDE6 present at the retinal level.

Filitra addresses the issues with erectile mechanism in males. Well absorbed after oral administration, regardless of meals, vardenafil contained in Filitra has a pharmacokinetic profile substantially similar to that of sildenafil with peak plasma concentrations reached after about 1 hour and with a half-life of about 4-5 hours. It is metabolized in the liver by cytochrome P450 and is mostly eliminated as metabolites mainly via the bile and fecal route and to a small extent via urine.

The effects of Filitra last during 4-5 hours following the onset of effects. This time is approximate and is subject to change from one subject to another, and also depends on other factors such as meal intake, general health condition, etc. While Filitra remains active in the body, the user is capable of achieving and maintaining erection as many times as he becomes sexually aroused.

Filitra is manufactured by an Indian company Fortune Healthcare that specializes in producing generic drugs. This pharmaceutical company has been around for several decades and is a well-established name for itself, guaranteeing compliance with ISO 9000:2001 standards and the universally recognised Good Manufacture Practices protocols.

Filitra doses should be appointed by prescriber. The general rule is that the median dose of 10mg is universally well tolerated and gives good effects, but in case the effects appear to be insufficient, the dose can be increased to 20mg or 40mg. As in the case of tadalafil, the greater impactfulness does not translate into greater clinical efficacy but simply in the possibility of using lower doses than sildenafil (Viagra).

The differences between Filitra 20gm and Filitra 40mg lie with the response towards different doses of vardenafil; in patients with poor response towards Filitra 20mg a larger dose can appear more resultful. Be advised that Filitra 40mg contains maximal recommended dose of vardenafil, and its use should be approved by a healthcare practitioner.

The following side effects may occur when taking Filitra:

• headaches, visual disturbances, dizziness, increased muscle tone, drowsiness

less common side effects of Filitra are:

• dyspepsia, nausea
• pain in the lower back, rhinitis, laryngeal edema, muscle pain

If you are permanently or periodically experiencing cardiovascular disease, you should consult your doctor before use, since the risk of complications caused by the use of Levitra with sexual activity is great for you.

Filitra is not recommended to be used in patients with:

• cardiovascular diseases, to whom sexual activity is contraindicated:
• a stroke or myocardial infarction in the last six months
• blood pressure at rest is less than 90 mm Hg
• diagnosed high pressure
• unstable angina
• congenital QT interval prolongation
• aortic stenosis and idiopathic hypertrophic subaortic stenosis
• a serious degree of liver failure
• kidney disease that requires dialysis
• hereditary retinal degenerative disorders (eg retinitis pigmentosa)
• anatomical deformations of the penis (for example, patients with cavernous fibrosis curvature, Peyronie’s disease)
• leukemia, multiple myeloma, sickle cell anemia
• acute exacerbation of peptic ulcer and the tendency to bleeding
• hypersensitivity to the components of Filitra
• if the patient is taking drugs containing nitro (isosorbide dinitrate, nitroglycerin, isosorbide mononitrate), also nitric oxide donors
• if the patient is taking HIV protease inhibitors (ritonavir, indinavir)

Filitra is a generic medication analogous to the brand drug Levitra, with both medications being identical in their contents, safety and efficacy. The price for the brand Levitra is traditionally higher than for the generic equivalent. Generic vardenafil is currently only available only through online purchase, since its distribution in local pharmacies is restricted due to the existing patent regulations for vardenafil. However, importing the drug from another country where its generic production is certified is legal, inexpensive and convenient.