Basic Drug Info

Manufacturer:

Accord, AB, Mylan, 2care4, Ebb, APL

Active Substance:

Propranolol chloride

Drug Form:

Capsules, tablets, liquid solution

Available Doses:

10mg, 40mg

Product

Price Per pill Order

Revia.50mg x 10 tablet

€77.63€7.76Buy

Revia.50mg x 20 tablet

€144.96€7.25Buy

Revia.50mg x 30 tablet

Free shipping

€201.93€6.73Buy

Revia.50mg x 60 tablet

Free shipping

€372.84€6.21Buy

Revia.50mg x 90 tablet

Free shipping

€512.67€5.70Buy

What Is Propranolol?

Propranolol is a beta-blocker drug. It works by reducing the resting heart rate, the amount of blood pumped from the heart into the body, the minimum and maximum pressure and orthostatic hypotension. Propranolol is administered orally, usually in the form of capsules or liquid solution.

Propranolol is used in the treatment of tremors, angina, hypertension, heart rhythm abnormalities and other cardiovascular problems. It is also used in the treatment and prevention of heart attacks, to reduce the frequency and severity of migraines and in cases of hyperthyroidism, pheochromocytoma, menopause and anxiety.

Active Substance & Action Mechanism

Taking Propranolol may interfere with some laboratory tests. During the treatment it is good to avoid alcohol; it is also necessary to avoid getting up suddenly from a sitting or lying position, in order to avoid dangerous dizziness.

Dosage & Posology

propranolol-chloride

When you receive a prescription drug, the dose is appropriate for you. Therefore, follow the instructions that appear on the label on the pharmaceutical packaging. Propranolol, taken by mouth with sufficient amount of water, is rapidly absorbed at the gastro-intestinal level, reaching maximum plasma concentrations in a very short time (1 – 2 hours). The various metabolites produced at the hepatic level are subsequently excreted via the urine. It is mainly metabolised in the liver, where through a first-pass effect it gives rise to pharmacologically active metabolites; bound to plasma proteins, it can then spread freely through the circulatory stream.

Propranolol is usually taken twice a day. When treating high blood pressure and angina it is common to start with 160 milligrams a day. In irregular heart rhythms, 40-120 milligrams are usually taken daily, against tremors and migraine 120-160 milligrams daily.

Medical Applications

The therapeutic effects of propranolol, a non-cardioselective beta blocker with no intrinsic sympathomimetic activity, are mainly due to the cardiovascular action exerted through competitive inhibition against beta adrenergic receptors. This activity results in decreased frequency and cardiac output, an increase in the duration of the systole and a decrease in resting blood pressure; these effects allow a significant reduction in total oxygen consumption of the myocardium and cardiac work.

Another important activity, perhaps the main one, is the antiarrhythmic action of propranolol, which appears to be accomplished through a control of the discharge frequency of the cardiac conduction tissue.

The direct antihypertensive action, on the other hand, although widely observed in various clinical trials, has not yet been fully characterized.

Propranolol In Alcohol Abstinence Symptoms

alcohol-abstinence-symptoms

Beta blockers can control some of the physical symptoms of anxiety, such as tremor, tachycardia and sweating – the symptoms associated with alcohol abstinence syndrome. Propranolol is the beta-blocker that is used most often for anxiety disorders, its most common use is for the treatment of heart disease and high blood pressure. This drug can help those people who have physical problems related to anxiety. For example, when a person with social phobia faces a stressful situation, such as a speech, or attending an important meeting, a doctor can prescribe a beta blocker. Taking the drug for a short period of time can help keep physical symptoms in check, waiting for a drug that treats anxiety to begin to take effect.

Propranolol In Anxiety/Panic Attacks

Studies carried out and clinical efficacy include “The use of propranolol in the treatment of anxiety disorders” by Hillside J Clin Psychiatry. The scientific literature shows the efficacy of Propranolol in the treatment of anxiety disorders, although the molecular mechanism of action has not yet been clarified. Probably this effect seems to be linked to the action on the central nervous system, through a modest passage of the blood-brain barrier.

Propranolol In Hemangioma Treatment

Hemangiol is a medicine that contains the active substance propranolol. It is indicated in the treatment of children suffering from a proliferative infantile hemangioma, a benign tumor (abnormal growth of non-tumor tissue) of blood vessels. Hemangiol is used in infants with serious complications, including ulcers accompanied by pain, at risk of scarring and with difficulty breathing, which require systemic therapy (treatment that can have an effect on the whole organism). Treatment with Hemangiol should be started in children aged 5 weeks to 5 months.

hemangioma

The active substance in Hemangiol, propranolol, belongs to a group of medicines called beta-blockers, which have been widely used to treat a variety of conditions in adult patients, including heart disease and hypertension. Although the mechanism of action of Hemangiol in the proliferative infantile hemangioma is not precisely known, it is believed that more mechanisms are involved, including the narrowing of blood vessels and therefore the reduction of blood flow to hemangioma, the suppression of the formation of new blood vessels in the tumor mass, the induction of abnormal blood vessel cell death and the suspension of the effect of some proteins (called VEGF and bFGF), which are important for blood vessel growth.

Hemangiol was examined in one main study involving 460 children (aged between 5 weeks and 5 months at the start of therapy), suffering from a proliferative infantile hemangioma that required systemic therapy. The study compared different Propranolol doses with placebo (a dummy treatment); the main measure of effectiveness was the total or almost complete disappearance of hemangiomas after 6 months of treatment. Hemangiol, taken at a dose of 3 mg / kg per day (in two separate doses of 1.5 mg / kg) for 6 months, has been shown to be more effective than placebo. In about 60% (61 out of 101) of children treated with the most effective dose of Hemangiol (3 mg / kg / day for 6 months) the hemangiomas disappeared completely or almost completely, a result that was only observed in 4 approximately 2% of children treated with placebo.

Contraindications

Propranolol should not be taken in case of asthma or a strongly slowed heart rate. It is also contraindicated in case of some serious heart problems. Before taking it it is important to inform your doctor:

  • of allergies to the active ingredient, its excipients or other drugs or foods
  • of medicines, herbal medicines and supplements taken, in particular anticoagulants, antidepressants, heart or pressure medications, prostate drugs, FANs or steroid drugs
  • if you suffer (or have suffered) from asthma, slow heartbeat that leads to fainting, heart problems, muscular disorders, bronchitis, emphysema or other respiratory problems, hypoglycemia or diabetes, low blood pressure, liver or kidney disease, thyroid disorders , pheochromocytoma or circulation problems
  • in case of pregnancy or breastfeeding

It is also necessary to inform physicians, surgeons and dentists of the intake of Propranolol.

Propranolol is contraindicated in patients with bronchial asthma or bronchopathies, hypersensitivity to one of its components, marked bradycardia, cardiogenic shock, hypotension, metabolic acidosis, renal failure, atrioventricular block, pheochromocytoma monotherapy, prinzmetal angina and sinus node disease.

Concomitant use of dihydropyridine may determine the incidence of hypotensive crises;

The administration of cimetidine, hydralazine, ergotamine-based drugs, dihydroergotamine, prostaglandin inhibitors, glycosidic drugs, antiarrhythmics, alcohol and drugs with antidepressant action, can alter the normal pharmacokinetic characteristics of Propranolol, causing an alteration of biological effects with increased incidence of adverse reactions.

Furthermore, given a potential increase in the insulin effect and the masking action of propranolol on some signs of hypoglycemia, it is necessary to monitor blood glucose levels in diabetic patients and possibly correct the hypoglycemic drug dosage.

Side Effects

Possible adverse effects of Propranolol include:

  • diarrhea
  • nausea
  • vomiting
  • constipation
  • stomach cramps
  • insomnia
  • fatigue

You should contact a doctor immediately if you experience:

  • slow or irregular heartbeat
  • lightheadedness
  • wheezing or difficulty breathing
  • shortness of breath, swelling, rapid weight gain
  • sudden weakness, vision problems or loss of coordination
  • cold hands or feet
  • depression, confusion, hallucinations
  • nausea, pain in the upper part of the stomach, itching, feeling tired, loss of appetite, dark urine, clay-colored stools, jaundice
  • headache, hunger, weakness, sweating, confusion, irritability, dizziness, rapid heartbeat, agitation
  • in children: pallor, cyanosis or redness of the skin, sweating, crying, refusal of food, cold, drowsiness, weak or shallow breathing, convulsions or loss of consciousness
  • severe skin reactions

Posted in Heart Disease, Drugs

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Customer reviews

By Levvy,

Thursday 21st of November 2019

I am on therapy for complex partial epilepsy. I take (daily): levetiracetam, clonazepam, amitriptyline, propranolol and Pineal at bedtime. Propranolol makes me tired during the day, and I feel like I’ve gone overtraining. I am 56 years old and I practice competitive swimming. In the absence of therapy I always have regular pressure and a resting heartbeat (between 43 and 60) low; as many athletes, I have bradycardia. I underwent a visit to a Sports Medicine Center for the evaluation of fitness for competitive practice, I went without therapy for 2 months, in January, and everything was ok. In which sports is propranolol prohibited?

By James Daniels M.D,

Friday 22nd of November 2019

Dear reader, this question should not be directed at your prescriber, but rather at the committee of the sports you are engaged in- I suggest you talk to your specialist to decide what to do in your specific case. Regards

By Cornelia,

Sunday 24th of November 2019

I would like to learn more about Propranolol and if it is used to erase bad memories that unfortunately cause me anxiety, panic attacks and phobias. Can I take it and in what doses?

By James Daniels M.D,

Monday 25th of November 2019

Propranolol is sometimes used to reduce some physical symptoms of anxiety. Therefore, this drug does not make you let go of bad memories, but reduces some symptoms (tachycardia, tremor, sweating) produced by the anxiety that is generated by remembering negative episodes. It is therefore a therapy that almost never has a significant effect, if not associated with other more specific drugs for anxiety disorders. In any event, your doctor should be consulted for the appointment of anti-anxiety medications in the correct doses.

By Arlen,

Wednesday 1st of January 2020

What is a good trigeminal inflammation therapy? For 15 days I started as a prophylaxis for migraine 1/4 Propanolol in the morning and 1/4 in the evening and 1/2 metergoline at lunch and 1/2 at dinner, only that an inflammation of the trigeminal arose; can this therapy help me?

By Dr Kaufman,

Saturday 4th of January 2020

I am a little surprised by this preventive migraine therapy. Why two low dose drugs? And above all metergoline is practically never used. I would try to suspend it and increase Propanolol 40 mg to 1/2 cp x 2, on the advice of your doctor. If trigeminal pain persists (which branch? What are the characteristics? Striking, continuous abscess with trigger points?) The symptomatic picture changes the therapeutic orientation. Talk to your doctor.

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