What is Amoxicillin 500mg?
Amoxil (Amoxicillin generic brand) is a broad-spectrum antibiotic that is characterized by an antibacterial effect extending to gram-negative and gram-positive pathological microorganisms. The medication is intended for use in the treatment of infectious diseases of various localization. Amoxicillin has a fairly low toxicity, but it is characterized by a good therapeutic effect. This provides an opportunity to use a pharmacological agent in pediatric practice with the least negative consequences for a developing child’s body.
The active substance of Amoxil is amoxicillin trihydrate. It belongs to the category of aminopenicillins and is characterized by a wide range of effects. The action of Amoxil technically stops the synthesis of bacterial cell walls. It prevents the cross-linking of linear polymer chains of peptidoglycan, thereby depriving the bacteria of the main element involved in the synthesis of cell walls.
Important: Amoxicillin is not efficient against fungi, mycoplasmas, amoeba, mycobacteria, rickettsia, plasmodia, and viruses.
What is Amoxicillin 500mg used for?
Amoxicillin has found wide application in the therapy of many diseases of a bacterial nature. It is used in the treatment of infectious diseases of:
- respiratory organs and other ENT organs, including tonsillitis, sinusitis, otitis media, inflammation of the pleura, lungs, and bronchi (meaning inflammation caused by bacteria, not viruses);
- organs of the genitourinary system: cystitis, pyelonephritis, urethritis, pyelitis, as well as other lesions, the pathogens of which are sensitive to amoxicillin. Also, the drug is used to treat gonorrhea (STIs);
- intestines dysentery, salmonellosis, etc.;
- soft tissue, skin.
In the treatment of gastric and duodenal ulcers, Amoxil can be used as part of complex therapy against the bacterium Helicobacter pylori. In these cases, the drug is usually prescribed in conjunction with clarithromycin, metronidazole, etc.
In dentistry, penicillin antibiotics, including amoxicillin, are applied very widely for inflammation of the gums, gumboil, and many other purulent-inflammatory processes. Amoxicillin dosage in this regard is very convenient for use since it can be prescribed to patients of any age.
Doctors prescribe Amoxil for many other bacterial infections, but the laboratory-proven sensitivity of the pathogenic microorganism to amoxicillin always remains the main condition for the appointment. For example, Staphylococcus aureus, Klebsiella, Chlamydia, Mycoplasma, Legionella, and many other microorganisms are not sensitive to amoxicillin.
Amoxicillin 500mg dosage for adults
Under various conditions, different doses of Amoxil may be recommended. Typically, factors such as body weight, the kind of bacteria provoking the infection, and the type and severity of the condition are evaluated by the doctor before determining the correct dose. Patients are advised to follow the prescribed dosage strictly.
It is preferable to distribute the load during the day at regular intervals (12-hour intervals when taking the drug twice a day or 8-hour intervals when taken three times a day). Stopping Amoxicillin treatment before the end of the specified period may lead to undesirable consequences, for instance, bacteria may become resistant to antibiotics and other drugs. Most common dosage of Amoxicillin 500mg – 3 times, but it depends on many factors: the diagnosis, the weight, and age of the patient, the presence of contraindications, the sensitivity of bacteria to amoxicillin, etc. Accordingly, how to take Amoxil for adults and children in each individual situation should be decided exclusively by an experienced doctor.
Instructions for the use of this medication give average dosages for patients of various ages in the presence of different indications.
The standard dosing regimen for different age categories is as follows:
- Adults with chronic diseases and relapses are prescribed 750-1000 mg three times per day, children 60 mg per 1 kg of body weight, split into three doses;
- Children from 10 years old and adults in cases of mild to moderate infections 500-750 mg twice a day, or 375-500 mg three times a day;
- For children 3-10 years old, twice a day, 375 mg or, three times a day, 250 mg of Amoxil.
In this case, depending on the diagnosis, the dosage of the drug can vary significantly. Also, the dosage of the medicine should be reduced (sometimes by half) if the patient has kidney disease. In this case, the doctor, when prescribing, focuses on the indicators of creatinine clearance.
Side effects of Amoxicillin
Amoxil can cause allergic reactions: urticaria, angioedema, erythema, conjunctivitis, and rhinitis, less often in the form of eosinophilia, joint pain, fever, and anaphylactic shock.
Diarrhea, vomiting, the occurrence of superinfections, nausea against the background of the use of Amoxil is also possible. When taking Amoxil simultaneously with metronidazole, anorexia, nausea, constipation, vomiting, diarrhea, pseudomembranous colitis, stomatitis, glossitis, pain in the epigastric region are possible, hepatitis, hematopoietic disorders, and interstitial nephritis are less common. With prolonged use of Amoxil, convulsions, dizziness, depression, loss of consciousness, ataxia, and periodic neuropathy were observed.
It is recommended that during the use of Amoxil in high doses, maintain adequate diuresis and take a sufficient amount of fluid since there is a possibility of developing crystalluria. It is important to bear in mind that repeated or prolonged use of the drug can lead to the development of superinfections and the rapid growth of resistant microflora. Children taking the medication must follow the rules of oral hygiene since the active substance Amoxil can change the color of tooth enamel. Patients whose professional activities are related to driving vehicles and operating mechanisms should be prescribed Amoxil with caution since the drug causes adverse effects on the nervous system.
Actions in case of overdose
With an overdose of Amoxil, diarrhea, nausea, vomiting, and a violation of the water and electrolyte balance occurs. In this case, you need to urgently rinse the stomach and take enterosorbents and saline laxatives. It also requires correction of the water and electrolyte balance and, in some situations, the use of hemodialysis.
Amoxil’s instructions indicate that it is impossible to take the drug if the patient has increased sensitivity to penicillins or cephalosporins. Also, Amoxil is not used for infectious mononucleosis, during pregnancy, breastfeeding, hematopoietic disorders, lymphocytic leukemia, and diseases of the nervous system. In addition, if there is sensitivity to nitroimidazole derivatives, Amoxil should not be taken simultaneously with metronidazole.
With a one-time use of Amoxil with hormonal contraceptives, a decrease in the effectiveness of the latter is possible.
The drug causes increased absorption of digoxin and toxicity of methotrexate.
The excretion of Amoxil slows down when combined with indomethacin, acetylsalicylic acid, probenecid, sulfinpyrazone, and phenylbutazone.
Preparations with a bacteriostatic effect neutralize Amoxil.
Antacids, in combination with Amoxil, reduce its absorption.
What can substitute Amoxil?
If there is a need to replace Amoxil with another drug, the doctor can substitute it with:
- another antibiotic of the penicillin series;
- an antibiotic that is not related to the penicillin series.
There are several alternative medications that your doctor may recommend, such as Trimox, Apo-Amoxi, Moxilin, Moxatag, and Amoxicot.
In each individual case, there must be very good reasons for changing the drug, for example, laboratory-proven ineffectiveness of amoxicillin or severe adverse reactions of the body to it.
Amoxicillin Over The counter
Unlike similar drugs, for example, ampicillin and benzylpenicillin, Amoxil pills are quickly absorbed into the blood. As a result, the required concentration of the active component is achieved in a short period of time.
Another useful property revealed as a result of the use of Amoxil is resistance to the effects of gastric juice. This makes the antibiotic well-suited for oral use.
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