What is Priligy?
Priligy (dapoxetine) is a premature ejaculation (PE) medication administered orally. Up to date, Priligy is the only a delaying pharmacological response, Priligy, a systemic drug administered orally with action in the central nervous system based on dapoxetine, a molecule that belongs to the class of drugs used as antidepressants (SSRI inhibitors, selective serotonin reuptake inhibitors). The drug is taken on demand, which means before a sexual activity is planned.
Mechanism of action
Dapoxetine, the active component in Priligy, is a SSRI designed specifically for premature ejaculation. Researchers at the University of Minnesota in U.S.A. published in the prestigious scientific journal Lancet a work with which they tested the effectiveness of dapoxetine. The study involved 2600 men, of whom 870 received placebo, 874 a dose of 30 mg dapoxetine and 870 a dose of 60 mg. Ejaculation times went from one minute and 75 seconds for men who took placebo to three minutes and 32 seconds of those who had taken dapoxetine at a dose of 60 mg.
Recent scientific studies link premature ejaculation to a serotonin deficiency and justify the use of SSRI antidepressants. This type of drugs – together with tricyclics, however considered less relevant than the former – is today effective in the pharmacological treatment of premature ejaculation, even if their side effects often do not justify the benefits of this solution.
As is known, premature ejaculation can be treated both at a therapeutic and psychological level, with psychological support from an expert in psychosexual problems, and at a pharmacological level.
The pharmacological treatment involves the use of antidepressant drugs such as SSRIs, and, in the most difficult cases or in the case of non-improvement with the first type of antidepressants, the use of tricyclic drugs which however contain a greater risk from the point of view of side effects.
How to take Priligy
A tablet of Priligy is taken on demand, 30 to 60 minutes before the planned sexual activity. A tablet should be taken as a whole with sufficient amount of water. Never take more than one recommended Priligy dose; do not combine the drug with alcohol.
How long do effects of Priligy last?
Dapoxetine half-life is 2 to 3 hours. Dapoxetine should be taken an hour and a half before sexual intercourse. As a result, patients can usually expect the ejaculation time to double.
Contraindications and precautions
Priligy is contraindicated against the background of the following health conditions:
- bipolar disorders
- history of mania or depression
- history of drug abuse
- renal insufficiency
- hepatic insufficiency
This list is incomplete and is a subject to elaboration by certified doctor.
The long elimination half-life of both dapoxetine and norfluoxetine should be kept in mind with pharmacodynamic or pharmacokinetic type interactions (eg changing from dapoxetine to other antidepressants) should be considered. Combinations with irreversible, non-selective monoamine oxidase inhibitors (eg iproniazid) are prohibited: sme cases of severe and sometimes lethal reactions have been reported in patients treated with an SSRI in combination with an irreversible, nonselective monoamine oxidase (IMAO) inhibitor. These cases presented similar characteristics to the serotonin syndrome (which can be confused with (or diagnosed as) malignant neuroleptic syndrome). Ciproeptadine or dantrolene may help patients with these reactions.
Side effects such as nausea, diarrhea, headache and dizziness given by Priligy are mild and transient. High efficacy in combination with low side event profile makes Priligy an optimal drug for the treatment of premature ejaculation.
Cialis and Dapoxetine
Cialis Super Force is a combination drug containing tadalafil citrate and dapoxetine. The use of this combination of drugs is justified in subjects whose PE problem is aggravated or even caused by another sexual disorder, erectile dysfunction (ED). Tadalafil (Cialis) is used to treat ED, the efficacy of the substance lasting for approximately 36 hours.
Given that SSRI are reported to have detrimental effect on erectile function, Cialis and dapoxetine can be used concomitantly in order to prevent the onset of ED symptoms.
Levitra with Dapoxetine
Levitra (vardenafil) is yet another ED drug, but unlike Cialis, it has a milder and less durable effect whose half-life is closer to that of dapoxetine. The use of this combination therapy is advisable in men suffering from both ED and PE or against the background of particular susceptibility towards debilitating effects of dapoxetine on erectile function.
Super P Force
Super P Force is a combinatory drug containing dapoxetine and sildenafil, the main ingredient in Viagra, which was the first ED drug to be presented on the pharmaceutical market, and until present day remains one of the best-studied and impactful drugs aimed at symptomatic relief of ED. Used alongside each other, sildenafil and dapoxetine make for an ultimate sexual enhancer.
Sildenafil can also be used as part of PE treatment in subject suffering from PE linked to compromised erectile ability and associated performance anxiety.
Premature ejaculation treatment
The use of drugs for premature ejaculation capable of delaying the male orgasm and thus lengthening the duration of sexual intercourse is a very hot topic for both the patient and the doctor, but it is also much debated in the medical profession. Some specialists believe that drugs are not necessary for treating the disorder because, according to them, the precociousness of ejaculation is the consequence of psychological anxieties and fears and because possible side effects could overcome the hoped for therapeutic benefits.
Other doctors, on the other hand, are in favor of using specific drugs because they are convinced that their administration – regardless of the cause of the ejaculatory disorder – may produce benefits not only on the anxiety and worry that afflict the patient at the time of the sexual act but also on the control of ejaculation.
However, it must be emphasized that each individual responds in an own and unique manner to excitatory stimuli, so that if a man can overcome the problem by consulting only with the specialist, another can instead request the administration of drugs with an “immediate” effect for to cure this sexual disorder.
Since various researches suggest that the ejaculatory precocity is due to functional deficits of some substances very important for the functioning of the brain and nervous system, one of which is serotonin, one of the treatments used for premature ejaculation is based on the administration of drugs capable of correcting the action of serotonin, thus prolonging the duration of sexual intercourse; these are usually so-called anti-depressants. Not surprisingly, in fact, a side effect of these drugs (exploited therapeutically in these cases) is precisely the ejaculatory delay. However, other side effects of these unwanted and annoying drugs are nausea, dry mouth, drowsiness and, paradoxically, a drop in libido.
Where to buy Priligy online
Generic Priligy is a prescription drug with a certain number of contraindications that pose serious health risks when ignored or when the drug is acquired by circumventing existing prescribing instructions. Remember that self-diagnosing and self-medicating risks far outweigh possible benefits, therefore consulting a certified physician, urologist or andrologist is a necessary condition to buy Priligy online.
Generic Priligy is available in a large number of online pharmacies. It is important to choose an e-commerce drug supplier with utmost care. It is necessary to make sure that the pharmacy provides high quality medications whose content corresponds to industry’s standards. Ordering Priligy with home delivery should not take more than several minutes, but will be considerably more economical thanks to generally lower cost of items purchased online, pharmacy drugs including.
- Poxet – Sunrise Remedies
- Priligy – Johnson & Johnson
- Dapolast – Micro Labs Ltd.
- Dapox – Ranbaxy Laboratories Ltd.
- Dapoxy – Alembic Ltd.
- Justinex – Emcure Pharmaceuticals Ltd.
- Prilyxet – Sun Pharma Laboratories Ltd.
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