What is Zenegra?
Zenegra (sildenafil citrate), a drug to be taken by mouth, is a generic version of universally recognized Viagra, which is a medication used to treat erectile deficit. Zenegra is intended to be taken as needed, some time in anticipation of sexual activity. The drug can help restore erectile ability caused by a broad spectrum of causes in men across age strata. The health benefits of Zenegra are experienced against the background of relevant sexual stimulation.
What is sildenafil? Mechanism of action
Sildenafil is the active substance engaged as chemical basis of Zenegra. Phosphodiesterase type 5 inhibitors (PDE5i), the class of drugs to which Zenegra belongs, are vasoactive substances (their action consists in relaxation and consequent expansion of blood vessels). PDE5 is the enzyme found predominantly in the smooth muscles of male genitals; in this way, its inhibition in this area promotes release of cyclic guanosine monophosphate, and consequentially, nitric oxide – the chemicals that increase elasticity of blood vessel walls.
It is thanks to this mechanism, described in a simplified way, that blood circulation is improved in the penile structures (the two corpora cavernosa, or cavernous bodies, and the corpus spongiousum, the spongeous body) responsible for erectile function. Blood is absorbed and “trapped” in the penis when Zenegra user is exposed to sexually stimulating experiences, and erection can be maintained long enough for a satisfactory sexual act to be conducted.
Erection achieved in a state medicated with Zenegra will subside in a natural way after ejaculation. The entire process of erection development, climaxing and return to flaccid state of the penis thus happens in a natural way, with the drug’s only role being that of inhibiting the substance that prevents occurrence of healthy erection in individuals affected by ED:
Clinically effective doses of sildenafil range from 25 mg to 100 mg. Zenegra is available in forms of pills containing 25 mg, 50 mg and 100 mg of sildenafil. Ask your doctor to prescribe the initial dose of Zenegra that is appropriate for your health condition. As a rule of thumb, the initial dose is established based on general health condition, the presence of comorbidities ailing the patient, severity of the main disease (ED in particular), the response to the drug and tolerance of the active substance.
Men without particular indications should start from the dose of 50 mg and increase it under professional supervision in case it does not yield desired health effects. Dose decrease is indicated in case side effects are persistent or intolerable.
Zenegra is intended for per os administration. The pill is supposed to be swallowed, at least 60 minutes prior to intended sexual activity, with a sufficient amount of water, as a whole. Chewing, crushing or breaking the tablet in the mouth cavity is not recommended.
Taking Zenegra with or without meals is a matter to be decided on based on the presence of side effects. Meals taken close to Zenegra administration diminish the risk of side effects; however, heavy meals and food high on fat content delay and decrease effects of the drug. Zenegra effects are considerably inhibited by alcohol.
Recommendations for use
Zenegra is taken on an empty stomach and goes into action within 30 – 60 minutes with a maximum effect duration of 4 hours. If it is taken after a meal, the effect can be delayed, and side effects include visual disturbances, headaches and hot flushes.
It has been reported as the result of numerous practical studies that the few initial intakes of Zenegra have limited efficacy which then improves progressively as the therapy advances. You should therefore keep up with your dosing schedule, never taking than one recommended dose during the period of 24 hours, for a certain stretch of time, before you can conclude if the drug has the desired health benefits for you.
Sildenafil vs tadalafil
Tadalafil is better known as Cialis. This drug starts to work within 30-60 minutes but its action lasts up to 36 hours. This is why it is also known as the “weekend pill”. Cialis also has its side effects, even if a little different compared to those of other PDE5i. They are: muscular pains, back and neck pain, some forms of headache and gastric reflux.
Sildenafil and tadalafil are both drugs as the first-line therapy of erectile deficiency in male patients. They both belong to the same drug class of PDE5 inhibitors. The differences between the drugs, as well as their similarities, can be summed up in the following table:
Sildenafil vs. vardenafil
Another molecule similar to sildenafil is vardenafil or Levitra, which has an almost identical profile and goes into action in about 30, at most 60 minutes. Vardenafil is yet another substance from the class of PDE5i used to restore erectile ability in males. This drug should also be taken on an empty stomach (with the meal absorption tends to be delayed). It lasts about 5 hours and there is also an orodispersible formula. Among the possible side effects of vardenafil there are headaches and visual disturbances (such as tearing).
As compared to sildenafil and tadalafil, it has milder side effects and is therefore more often prescribed to men with other health conditions to be taken into consideration, such as kidney or liver insufficiency, heart condition, diabetes, etc. In its pharmacodynamic effects, vardenafil is closer to sildenafil than to tadalafil, which is illustrated in the table below:
From the data in our possession, one person out of ten, at the most, can experience headaches, redness in the face, burning in the stomach, myalgia and back pains. However, Zenegra is a completely harmless drug. It can become dangerous when it is administered without medical supervision or if the patient has heart disease and takes nitrates.
In fact, the combination of these treatments can cause a drop in blood pressure until it collapses. Although considered safe, these drugs require a medical prescription. It is important, in fact, that the specialist checks the causes of erectile dysfunction. It is often possible to resolve the disorder in a natural way, by changing one’s lifestyle, for example by stopping smoking or increasing physical activity.
The best therapy for those suffering from erectile dysfunction remains the combination of pharmacological and psychological treatment. Only in this way can lasting results be achieved.
Zenegra should be used with extra caution in the following individuals:
- with compromised kidney clearance
- over 65 years of age
- patients coadministering alpha-blockers
Alcohol consumption should be limited to insignificant amounts when undergoing sildenafil treatment. Larger amounts of alcohol can increase vasodilatory effects of sildenafil and cause a sudden and abrupt drop in blood pressure that can be life-threatening.
- Allergies (a component of the drug). In this case the doctors recommend replacing it with other drugs, having the same efficacy: Cialis, Levitra or their analogues;
- Severe hepatic insufficiency (class C in the Child-Pugh classification);
- Acute peptic ulcer or duodenum ulcer;
- Severe arterial hypertension;
- Arterial hypertension;
- Arrhythmia that leads to the danger of life;
- Chronic heart failure;
- Unstable forms of angina pectoris;
- Blood diseases: thrombosis, leukemia, sickle cell anemia, predisposition to bleeding;
- Malignant brain tumors;
- Kahler-Cocoon disease;
- Priapism predisposition,
- Genetic penile malformations of the penis;
- Female sex.
- Men who have had a stroke or heart attack are not allowed to take Zenegra during six months after recovery.
The administration of the drug is contraindicated in the event of prohibition of physical or sexual activity.
Where can you buy Zenegra over the counter?
Zenegra can be purchased online without prescription, which does not, however, exempt one from visiting the doctor and obtaining one. Medical consultation is a must with drugs that act as vasoactive agents, since they interfere with cardiovascular system of the body. Contraindicative conditions should be ruled out before you proceed with taking Zenegra.
Always order Zenegra from drugstores that have the attributes of reliable e-tailers: contacts, customer support, comprehensible policies of money back, etc.
- Caverta – Ranbaxy Laboratories Ltd.
- Edegra – Sun Pharma Laboratories Ltd
- Eriacta – Ranbaxy Laboratories Ltd.
- Instarise – Macleods Pharmaceuticals Pvt. Ltd.
- Manforce – Mankind Pharmaceuticals Ltd.
- Nizagara – Uni-Sule Private Ltd.
- Omnigra – Cipla Ltd.
- Penegra – Ajanta Pharma
- Progra – Cipla Ltd.
- Sidnakind – Mankind Pharmaceuticals Ltd.
- Spegra – Emcure Pharmaceuticals Ltd.
- Viagra – Pfizer
- Viraha – Micro Labs Ltd.
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