Basic Drug Info
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What is Tadalis?
Tadalis (tadalafil citrate) was created specifically to solve the problems related to erectile dysfunction encountered by men. The drug helps to recover the ability to engage in natural sexual performance. Tadalis has an outstanding pharmacological feature of having a therapeutic window of 36 hours, which is the longest in its drug class. Another distinctive feature of Tadalis is that the drug is compatible with alcohol and its effects are not dampened by alcohol.
Tadalis is quite safe and effective, yet it is convenient in its use. This perfectly affects not only the physical state, but also the psyche. Thanks to its unique chemical properties, the drug works with high efficacy, helping to eliminate erectile dysfunction, by strengthening the flow of blood to the area of the small pelvis.
What is Tadalis SX?
Tadalis SX is yet another name under which Ajanta Pharma markets its tadalafil products. Other names are Tadacip, Generic Cialis and Cialis Super Active. The drugs produced by the Indian pharmaceutical company Ajanta Pharma are highly acclaimed for their efficacy, safety and bioavailability, as well as the precision with which they reconstruct the pharmacodynamic properties of the original drugs they are serve as analogs for.
How does Tadalis work?
The action of the drug is based on the inhibition of phosphodiesterase and the local stimulation of the circulatory system. The drug is prescribed to stabilize male sexual function, helps to reconstruct erectile ability for 36 consecutive hours (this is how long tadalafil therapeutic window lasts) without causing damage to health.
Pharmacological effect of the active principle establishes a series of indications for its prescription:
- erectile dysfunction of various severity and etiology;
- erection reduction, linked to psycho-emotional discomfort, after loss of self-confidence;
- micturition dysfunction in the presence of prostatic hyperplasia;
- treatment of abnormal or acute prostatitis (as an auxiliary medium);
- overall therapy of pulmonary arterial hypertension.
Treatment of these diseases is based on the mechanism of action of Tadalafil. Let’s see it in detail.
The maximum concentration of tadalafil in the blood is reached after approximately 2 hours after intake. The drug works for 36 hours. During this period it is possible to carry out the sexual act. The effectiveness of the action of the drug does not depend on the intake of meals, their content and the consumption of alcoholic beverages.
The effect of Tadalis consists of the following:
Getting absorbed in the blood stream, tadalafil provides the healing effect within 16 minutes of taking the pill. The drug acts on the tissues of the corpora cavernosa and arterial vessels, located in the groin area.
The drug promotes the production of the erection transmitter in its maximum quantity. Among other things, Tadalis raises the biological activity of nitrogen oxide, which allows achieving a fast and sustainable relaxation of smooth muscles. The general muscular tone of the cavernous wall structures is lowered.
The outcome of the aforementioned processes shows a gradual increase in the width of cavernous arteries and the volume of caves. Blood through the vessels reaches the organs of the small pelvis. The cavernous bodies, having a spongy structure, are filled with a large volume of plasma and are enlarged in size. This causes the penis to swell.
The mechanisms, which manage the venous outflow, undergo changes. The cavernous bodies, which have absorbed the maximum amount of blood and thanks to their remarkable and consequently increased in size, block the veins. Eventually the venous pathways lose their ability to transfer blood out of the intimate area. In addition to increasing the volume, penile hardness is observed. Given a large amount of arterial blood collected therein, the penis acquires the hardness sufficient to enter the vagina.
This allows performing a complete sexual act, which ends with an orgasm. At the end of the act noradrenaline is released into the body. It is an organic substance that promotes arrest and a subside in erection.
Venous blood outflow restarts and the penis returns to its natural relaxed state. A similar mechanism also has other world-famous erection restoration drugs. Keep in mind that no drug will give the desired effect if the indicated dosages are not respected.
Tadalis proper dose
Regardless of the method of intake chosen, tadalafil alleviates the symptoms of erectile dysfunction. Lower doses of the drug are used as part of everyday therapy with an outlook to completely cure the disease.
Ask your healthcare practitioner, GP, andrologist, sexologist, urologist or pharmacist to appoint the right dose of tadalafil for you and always adhere to the recommendation of the specialist.
Table 1. Guidelines for Tadalis dosage
|Tadalis average dose||Tadalis maximal dose||Tadalis daily dose|
The recommended initial dose of the drug is 10 mg. It is also a recommended average dose for the majority of users.
The maximum dose of the drug is 20 mg in 36 hours. It is suitable for men who lead an irregular sex life, no more than two sexual contacts a week.
The minimum or continuous dose is 5 mg in 24 hours and can be recommended for men who have the possibility of having sex more often than 3 times a week. Dependence was not detected in cases of continuous administration. Conversely, the increase in the effectiveness of the drug and the presence of the curative effect after the 5 assumptions was noted.
Is Tadalis safe?
Tadalis is part of the group of drugs called 5PDE inhibitors. It acts only in the presence of natural excitement and in the male organism does not make any difference to that which has already been foreseen by nature. Otherwise said, the drug based on tadalafil does not make a mutagenic effect, it does not lower the concentration of testosterone in the plasma and the ability of fertilization. Tadalis is a renowned pharmaceutical medium that has nothing to do with supplements or aphrodisiacs.
Recommendations for use
Tadalafil does not contain molecules that interact with ethanol contained in alcohol. For this reason in the instructions for use it is indicated that the drug may be associated with alcoholic beverages. “Moderate intake” of alcohol is a fairly vague concept and depends on the health of each individual man. The recommended average quantities are as follows:
- 100 grams of vodka or other spirits
- about 300 g or a couple of glasses of wine or champagne
- 500 gr of beer.
Erectalis vs Tadalis – what is the difference?
Tadalis and Erectalis feature the same active component in the identical dose, and are applied for identical purposes. Their health effects and safety fully coincide; the drugs are manufactured by different pharmaceutical companies, both of which are based in India. All of the facts mentioned above make Tadalis and Erectalis drugs interchangeable.
Table 2. Tadalis vs. Erectalis
|Drug Name||Active Substance||Dose||Manufacturer|
|Tadalis||Tadalafil citrate||20 mg||Ajanta Pharma Ltd., India|
|Erectalis||Tadalafil citrate||20 mg||Cipla Ltd., India|
Be advised that postprandial intake of Tadalis can dampen any eventual side effects of tadalafil, making them more tolerable. Common side effects of tadalafil use are myalgia, headache, nausea, diarrhea, flushing of the face, drop in blood pressure.
Seek medical help urgently if you experience severe allergic reactions like pain in the chest or arm, swelling of the face, or skin hives.
It is contraindicated to combine Tadalis with certain groups of drugs, which could cause the uncontrolled lowering or increase of the effect of the active ingredient tadalafil, and yet lead to unwanted or even dangerous states of health.
Table 3. Tadalis Drug Interactions
|Group Of Drugs||Interactions With Tadalis|
Nitrates, nitrites of nitrogen:
Tadalis increases the hypotensive action of nitrates. Interaction with these types of drugs is contraindicated, as they may eventually lower the blood pressure to the critical level, which could endanger life.
Other medications treating erectile dysfunction:
Doctors do not recommend the interaction of multiple drugs that restore erection, because they have similar mechanisms of action and their combination could lead to overdose or side effects. For example, taking Tadalis and Arginine together could lead to too high a level of nitric oxide in the blood, which will lead to a sharp drop in blood pressure. The same applies to vardenafil in combination with sildenafil.
Antidepressant drugs used to delay ejaculation:
The exemption only concerns the intake of Priligy together with Tadalis. The active ingredient dapoxetine is a selective inhibitor of serotonin reuptake, it helps to increase the strength and duration of erection, delay orgasm in the patient suffering from premature ejaculation. The simultaneous use of these two drugs is to be evaluated as an overall therapy to treat erectile dysfunction, but it is only possible in the case of compliance with the following recommendations:
It is not recommended to combine the erection regulator together with Rifampicin and Erythromycin. The fact is that these antibacterial drugs react with the inhibitor components. A combined intake of antibiotics and Tadalis could result in an overdose of the active ingredient tadalafil.
There are no explicit contraindications to the combined administration of Cardioaspirin and Tadalis in the package leaflet. But before taking it, it is better to carry out cardiological examinations, because cardiovascular diseases could be detected, as they are prohibited from taking tadalafil.
In the case of combined administration with some of the hypotensive drugs, patients may experience an uncontrolled lowering of blood pressure. Therefore, the combination of tadalafil with doxazosin should be avoided. In the event of interaction, all of these drugs increase the risk of a sudden constriction of blood vessels and a subsequent fainting.
The only exception is tamsulosin (combined with Tadalis does not involve a strong action on blood pressure values, using the minimum dose of drugs).
In case of violation of the aforementioned limits and the combined intake of incompatible drugs between them, the following somatic symptoms can be expected:
- change in heart rate;
- acute headache;
- general weakness and rapid loss of strength;
- dizziness and fainting;
- worsening vision and hearing;
- hypersensitivity reaction.
Consult a healthcare provider for a full list of Tadalis contraindications, to which belong (fragmentarily):
- eye neuropathy (NAION)
- retinitis pigmentosa
- Peyronie’s disease
- allergic sensitivity towards tadalafil, lactose or Tadalis excipients
- heart failure
- stroke in medical history of the past 6 months
- ulcerative disease of stomach or duodenum
- kidney or liver insufficiency