Drugs Archive - Page 5 of 6

Caverta

What is Caverta?

Caverta is a tablet used to restore the ability to achieve erection. The drug’s main component is sildenafil, which makes Caverta a generic of the flagman erectogenic drug Viagra. Caverta is designed to be used on demand, that is shortly before the sexual activity is planned. It takes under 60 minutes for the medicine’s effects to set in, after which the drug continues to be effective during at least 4 hours.

How does Caverta work in the body?

Caverta Caverta mechanism is based on the ability of sildenafil to promote blood circulation, in particular in the penile area. This particular selectivity is achieved thanks to the inhibition of the enzyme referred to as phosphodiesterase type 5 (PDE5) – the characteristic that gave the name to the entire class of drugs called PDE5 inhibitors and used almost interchangeably. Inhibition of pDE5 allows to foster production of nitric oxide, which is the substance responsible for elasticity of the blood vessels.

Since PDE5 is found mainly in the corpora cavernosa (the spongeous bodies) of the penis, this is exactly where the effects of Caverta occur, enabling a man to respond with a firm, hard and maintainable erection every time he is sexually aroused. However, Caverta does not have an effect of a libido booster and does not work in the absence of sexual stimulation.

What is the use of Caverta?

Sildenafil used in Caverta applies itself to a vast variety of medicinal purposes linked to its vasodilatory and hypotensive effects; however, as a part of Caverta, sidlenafil is used with the sole purpose of improving erectile ability in men with diagnosed ED (erectile dysfunction) of varied severity.

Caverta vs Viagra

Caverta-tablet Caverta and Viagra are two identical drugs containing the same active component, sildenafil, but produced by different manufacturers. The difference in name, dosages available, the appearance of the pills and, most importantly, the price, are explained by the fact that Viagra is a brand drug produced by the original developed, while Caverta 100 mg (Caverta 50 mg) is a generic medication. Traditionally, the original manufacturer charges a much higher price for its products, which his explained by the necessity to compensate for the amount of money spent on the development, testing and marketing stages of the drug existence.

Producers of generic drugs use the same ingriedients with materials quality / the standards of manufacture being the subject to the same regulations as the original drug, so the efficacy and safety of Caverta is parallel to those of Viagra.

The comparative review of Caverta vs Viagra is available in the table below:

Drug	Active Substance	Available Doses	Manufacturer	Per/pill price, approximate
Viagra	Sildenafil	25mg, 50mg, 100mg	Pfizer, US	$61.54
Caverta	Sildenafil	50mg, 100mg	Ranbaxy Laboratories, India	$0,36

Is Caverta safe with alcohol?

The short answer for it is: to a certain extent. It is best to avoid the combination of Caverta and alcohol, since both substances feature powerful vasodilatory action that can be mutually reinforced. This can lead to a sudden and uncontrollable drop in blood pressure.

The effects of Caverta, as well as general ability of a man to perform sexually, can be compromised by doses of alcohol exceeding 3 units.

Precautions

According to Caverta review tendencies reflecting user preferences, Caverta 100 is the most popular dosage form of the drug. However, this dose pertains to the higher end of the dosing spectrum and should be used with caution in individuals with slower creatine clearance, as well as patients exceeding 60 years of age.

Caverta is a prescription drug whose use, as well as the correct dosage, should be appointed by a doctor following a medical examination focused at excluding any possible contraindications.

Contraindications

Caverta cannot be used against the background of the following health conditions:

uncontrollable fluctuations in blood pressure
heart, liver, kidney disease
sickle cell anemia, leukemia and other diseases of blood vessels
penile angulation, scarring, Peyronie’s disease, priapism
stomach / duodenum ulcer
retinitis pigmentosa, NAION
bleeding disorders
concomitant administration of nitrates, anti-fungal and anti-retroviral drugs

Where to buy Caverta?

Caverta is a generic drug that is freely available on the Internet; Caverta online purchase requires minimal efforts on the side of the shopper, but medical consultation is always recommended before sildenafil is administered. To buy Caverta online, pick a reliable e-pharmacy that cooperates with licensed manufacturers of sildenafil (the real Caverta pill is produced by Ranbaxy Laboratories based in India).

Avana

What is avanafil?

Avana 50 is an oral drug used in male patients with confirmed diagnosis of erectile deficit. The drug is taken on demand, prior to sexual activity, with its action providing symptomatic recovery for the period of time that lasts between 4 and 5 hours.

Avana 100 has avanafil citrate as its basic active component. Avanafil 100, which has been on the market for a few years (having been approved for the treatment of erectile dysfunction in 2012), is very fast in the action that occurs within 15-30 minutes of taking it and has a duration of 4-5 hours and perhaps fewer side effects.

Avanafil Uses

strong-erection The active ingredient of Avana 200, avanafil, is as effective as other drugs in its family of PDE5 inhibitors, but it is better tolerated even at higher dosages. This is demonstrated by a study conducted by Italian researchers on about 2 thousand patients.

The analysis, conducted on the data of about 2 thousand patients enrolled in five different randomized and controlled clinical trials, shows that thanks to the peculiar pharmacological profile this molecule has a greater tolerability than the well-known first generation drugs of the same class. This characteristic can help to avoid the widespread abandonment of therapy among men with erectile dysfunction: up to 60-70% of patients stop taking the drugs within a year of the first prescription.

Avanafil 100 mg, the active ingredient of the avana 200 mg tablets can help men with erectile dysfunction to live sexuality without worries because those who hire them need not worry about it hurting, working or starting to work too late. In comparison with sildenafil, vardenafil and tadalafil, active ingredients with which it shares the mechanism of action, but which are part of the first generation of phosphodiesterase-5 inhibitors, it has the same efficacy but guarantees a lower load of side effects such as headache, congestion nasal, flushing, visual disturbances, back pain: moreover, even at the highest dose of avana 200mg, which has proven to be extremely effective, there is no risk of increased adverse events. This tolerability – he added – is very useful because we know that the prescription of a drug against erectile dysfunction is repeated after the first 3-4 months only by 62% of patients, after a year the percentage of abandonment of therapy goes up to 60-70%. These data suggest that men stop taking drugs for reasons other than a lack of efficacy: many stop because they do not tolerate illness, but adherence to treatment is essential for the treatment to work.

Avana Dosage

Avana pill is the safest of the hitherto developed oral drugs for the treatment of ED; it can therefore be used in the elevated doses of up to avana 100mg, speeding up the onset and providing more significant results faster and in a more intense manner.

This said, it is always of paramount importance to have your avanafil dosage and posology approved by certified member of medical board before you start taking avana 50 mg tablets. It is up to your prescriber to determine the maximal allowed dose of avanafil for you individually.

Is avanafil safe?

Avanafil is reportedly as effective against erectile dysfunction as first-generation drugs, but with fewer side effects. Avanafil, the active ingredient of so-called “love pills” is in fact better tolerated, even at higher dosages. Therefore, not presenting any risk of an increase in adverse events, it is therefore possible to continue the therapy without abandoning it, as in the case of up to 60-70% of cases.

All this, along with excellent efficacy, with a satisfactory effect in 80% of cases and also in the presence of severe erectile dysfunction, considering the safety profile of avanafil, makes it is reasonable to prescribe it at the highest dosage of 200 milligrams, especially in the most complex cases, to get a response faster.

Avana vs Viagra vs Levitra

The differences between avanafil, vardenafil and sildenafil (Viagra) are minimal, apart from the tadalafil which stands out as regards the duration of action; there are a number of phase 3 drugs in preparation with the sole aim of improving and personalizing the therapy. It is always mandatory to rely on a reference andrologist to verify the need and the right dosage of the erection drug therapy which, as we have seen, it can have certain benefits, but also side effects that should be known and avoided when possible.

Finally, one of the characteristics that make avanafill stand out is its mode of action: it acts very quickly, freeing the need to plan the relationship and making it more spontaneous. Let us not forget that the goal of erectile dysfunction therapy is the return to a natural and satisfying sex life: the characteristics of avanafil make it fit for purpose, given that 4 men out of 10 consider a drug that works within 20 minutes ideal.

Avanafil Side effects

Although rare, Avana side effects can manifest themselves as the following:

Hot flashes
Electrocardiographic alterations
Hypertensiona
Nausea
Dyspepsia
Diarrhea
Constipation
Headache
Vertigo
Back pain
Arthralgia
Nasopharyngitis
Nasal congestion
Sinusitis
Upper airway infections
Bronchitis

Avana Precautions

The lower probability of side effects depends on particular characteristics that make avanafil more selective than the “classic” medicines against erectile dysfunction; this feature also reduces the likelihood of interactions with other drugs (however, the absolute prohibition of taking it with nitrates that are used for angina pectoris remains) and eliminates the need to adjust dosages in the case of elderly patients, with diabetes or with insufficiency mild or moderate kidney disease, making the pill much easier to manage.

Avana Contraindications

avanafil-citrate The use of Avana is contraindicated in patients with:

kidney / liver impairment
heart failure / heart disease / stroke
inadvisability of sexual or any other physical activity
congenital eye problem called retinitis pigmentosa
eye nerve condition called NAION
a number of blood cell diseases
ulcerative diseases of GTI
sensitivity towards avanafil

Before proceeding to take Avanfil, inform your prescriber about current and past health conditions so that they make a fully informed decision as for risks to benefits ratio of avenafil therapy in your specific case.

Metformin

What Is Metformin?

Metformin hydrochloride is an antidiabetic drug of the biguanide derivative group, which lowers glucose concentration in plasma from the onset and after eating. Does not stimulate insulin secretion and does not cause hypoglycemic effects mediated by this mechanism.

Metformin hydrochloride has three mechanisms for anti-diabetic action.

Reduces gluconeogenesis and glycogenolysis, thereby decreasing the amount of glucose produced by the liver.
Increases sensitivity to insulin in the muscles, increasing the capture and utilization of glucose in peripheral tissues.
Reduces absorption of glucose in the intestine.

Metformin hydrochloride stimulates intracellular glycogen synthesis; increases the transport capacity of all types of transport systems that carry glucose through a cell membrane; positively affects the metabolism of lipids. It has been shown that metformin in therapeutic doses reduces the concentration of total cholesterol, low density lipoproteins and triglycerides. It was reported that during metformin application, the body weight of patients remained stable or decreased moderately.

How Does Metformin Works

Metformin reaches its maximal concentration in blood plasma (Tmax) within 2.5 hours after the intake. The reprted bioavailability of the drug administered in form of 500g or 850mg pills is 50-60% according to FDA. The absorption of Metformin is described as intense and incomplete in medical literature.

It is assumed that the pharmacokinetics of metformin absorption is nonlinear. When using the recommended doses of metformin and dosing regimens, stable plasma concentrations are achieved within 24-48 hours and are less than 1 μg / ml. It was reported that the maximum levels of metformin in blood plasma (Cmax) did not exceed 5 μg / ml, even with the application of maximum doses.

After oral administration of 850 mg, a decrease in peak blood plasma concentrations was achieved by 40%, a decrease in AUC by 25%, and an increase in the maximum plasma concentration of 35 minutes by 35 minutes. Clinical significance of these changes is unknown.

Metformin is to a small extent bound to plasma proteins in the blood. Metformin penetrates into erythrocytes. The maximum concentration in the blood is lower than the maximum concentration in the blood plasma, and is reached approximately at the same time. Erythrocytes are more likely to represent the second distribution chamber. The average volume of distribution (Vd) is 63-276 liters.

Glucophage Dosage

When co-administered with food, absorption of metformin decreases and slows slightly.

Metformin Uses

Metformin eliminates hyperglycemia, but does not cause hypoglycemia. Even in large doses, it does not stimulate insulin secretion by the pancreas, so hypoglycemia does not occur. The drug does not have any significant effect on the secretion of glucagon. cortisol, growth hormone and somatostatin.

Metformin is used in the following conditions:

type 2 diabetes with ineffectiveness of diet therapy and exercise regimen, especially in patients with excess body weight;
as monotherapy or combination therapy in combination with other oral hypoglycemic agents or in combination with insulin for the treatment of adults;
as monotherapy or combined insulin therapy for the treatment of children 10 years of age and adolescents.
reduced diabetes complications in adult type 2 and overweight patients who used metformin as a first-line drug after ineffective diet therapy.

Lasix is salable only under medical prescription. Lasix should always be used after consulting your doctor.

The indiscriminate use of Lasix, between athletes and non-athletes, in the search for the loss of a few pounds, exposes the body to serious side effects. Furthermore, it is always advisable to reiterate that weight loss is dictated by the elimination of liquids and salts and not by a real weight loss effect, understood as a loss of fat mass.

Metformin In Bodybuilding

Metformin is used for aiding in weight loss due to its ability to accelerate the oxidation of fatty acids and inhibit the synthesis of fats, although in different tissues affects several points of application, which is expressed in diverse changes in cellular metabolism. It is also proven that the absorption of carbohydrates from the digestive tract is reduced. Metformin activates AMP kinase, thereby reducing glucose levels by suppressing its synthesis in the liver (suppressing gluconeogenesis). Recent studies have shown that exercise does not affect the overall acidity of the blood, so while you are taking Metformin, you can exercise without restriction, thereby only increasing the effectiveness of the course.

Metformin As An Anti-Ageing Drug

A new study was conducted under the guidance of professors Wang Chih-chen and Liu Guang-Hui from the Institute of Biophysics of the Chinese Academy of Sciences. The researchers were able to demonstrate that long-term administration of small doses of Metformin to cell culture slows down cell aging, especially in diploid fibroblasts and mesenchymal stem cells.

Previous researches by the same group showed that a protein called “endoplasmic reticulum glutathione-peroxidase-7” (GPx7) plays a key role in regulating protein folding processes and maintaining redox homeostasis. Now, researchers have found that small doses of metformin increase GPx7 production by activating the transcription factor Nrf2.

The concentration of GPx7 decreases as the cell becomes “decrepit,” and artificially reducing the amount of GPx7 accelerates cell aging, the researchers said. It is also interesting that the chain “Metformin – Nrf2 – GPx7” plays a certain role in the aging process of worms, and the analogue of human GPx7 in the body of worms is necessary for metformin to have a positive effect on the life expectancy of animals.

These results combine to highlight the significance of the “Nrf2 – GPx7” signaling pathway for longevity and indicate the need to look for additional evidence that metformin can be useful as a means of increasing life expectancy in humans.

Metformin For Improving Insulin Sensitivity

Metformin increases insulin receptor sensitivity to insulin, improves glucose uptake by muscles. Reducing insulin during weight loss is necessary because this hormone contributes to the deposition of nutrients in the fat, especially if the main problem area – the stomach. Immediately after a meal, the level of glucose in the blood rises sharply, to which the pancreas responds and produces insulin, which in turn forces the tissues to consume glucose, string is as fat. That is why in almost all diets for weight loss it is recommended to consume fewer foods that causes a spike in blood sugar.

Finally, insulin causes hunger, so metformin helps to suppress hunger during weight loss. The effectiveness of metformin decreases with increasing acidity of the blood, so some authors recommend eliminating exercise during the course of Metformin, since exercise leads to the formation of lactic acid.

Metformin For Weight Control

Metformin is a safe drug approved by FDA for use in healthy individuals for the purposes of weight loss.

Follow the diet for weight loss
Eliminate simple carbs

improving-insulin-sensitivity

Metformin for weight loss is taken immediately before meals or during meals, the dose is selected individually. Most often prescribed 500-850 mg, 2-3 times a day (maximum dose of not more than 3000 mg / day). If you have diarrhea, dial down your carbohydrates. If you have nausea after taking metformin, reduce the dose. Slow increase in dose may improve gastrointestinal tolerance. Perform systematic aerobic training to maximize the effectiveness of the course.

If, after reducing the dosage, the symptoms of side effects have not disappeared, stop taking the drug and immediately seek medical attention, as there is a risk of lactic acidosis, which is fraught with death! In the event of signs of lactic acidosis, the patient is urgently hospitalized and, having determined the concentration of lactate, confirm the diagnosis. The most effective measure for the elimination of lactate and Metformin from the body is hemodialysis. Symptomatic treatment is also performed.

The duration of the drug should not exceed 18-22 days, after which you need a break for 1-2 months. A shorter break leads to the adaptation of the organism, and Metformin is not able to show the properties of a fat burner to the full. The course must be agreed with a medical specialist.

Metformin And Spironolactone: Concomitant Use In Polycystic Ovary Syndrome

Metformin taken at adequate doses (500 mg or 850 mg three times a day) has an anti-inflammatory action, partially reduces the production of androgens and is able to improve the rate of ovulation and reduce the risk of early abortion in pregnant women. This therapy is even more useful given the withdrawal from the market of silbutramine. Unfortunately, it is often not well tolerated by the patient and produces gastrointestinal disorders that induce suspension. It can also be given to thin women with insulin resistance.

An excellent result is obtained when Metformin is used alongside with the only preparation that can be used without risk of the group of antandrogenous drugs, Spironolactone which, besides having an antiandrogenic action, also has an antialdosteronic action and is therefore an anti-inflammatory and anti-atherogenic. Spironolactone reduces the hypoglycemic effect of metformin.

Metformin And Glipizide

Metformin is used as a part of combined anti-glycemic agent alongside with Glipizide. Glipizid is a second-generation sulfonylurea derivative that fosters secretion of insulin by the leaver thanks to its ability to minimize the threshold for pancreatic β-cell irritation with glucose. Glipizide increases glucose release and the degree of its binding to target cells. The drug’s efficiency is determined by the number of functioning β-cells. It inhibits aggregation of platelets, and produces a fibrinolytic, lipid-lowering and weak diuretic effect. Taken concomitantly, those to anti-glycemic agents complete each other’s action and provide more significant health outcomes in a more compact time span.

Clomid Vs Metformin

Metformin improves the response to therapies with ovulation-inducing drugs like Clomid (clomiphene citrate): in therapies with metformin and clomiphene citrate the ovulation rates and pregnancies are higher than to those with clomiphene citrate alone. Thus, Clomid and Metformin are two effective drugs to induce ovulation in patients with polycystic ovary syndrome, although it is not yet clear which of the two drugs is to be administered first.

The study, carried out by researchers from the Magna Graecia University and the University Federico II of Naples, involved 80 infertile, anovulatory (who do not produce eggs), suffering from polycystic ovary syndrome. Patients were allocated in two comparable groups by body mass index (BMI) and age. The experimental group was treated for 6 months with 1700 mg / day of Metformin, while the control group received Clomifene using an incremental dose protocol. The study showed that both Metformin 1700 mg / day and Clomifene represent two first-line approaches able to improve fertility in anovulatory women suffering from polycystic ovarian disease.

Metformin Side Effects

Do not take Metformin if you have one of the following conditions:

Kidney disease, accompanied by renal insufficiency
Heart failure
Another condition associated with elevated acidity of the blood
Do not take Metformin with other sugar reducing agents and other drugs without prior consulting a doctor.

Metformin rarely causes adverse events. The possible side effects of Metformin are:

Diarrhea (it is necessary to reduce the amount of carbohydrates consumed)
Headache (usually passes quickly)
Abdominal cramps
Nausea (need to reduce the dose of Metformin)
Increased gas formation (it is necessary to reduce the amount of carbohydrates consumed)
Lactic acidosis (in the presence of predisposing diseases), (do not combine with alcohol as it is associated with the risk of lactic acidosis)

As a rule, the side effects of Metformin occur at the beginning of the course, and then quickly pass. They can usually be minimized by increasing the dose of the drug gradually and taking it with food. With long-term treatment with metformin, the absorption in the gastrointestinal tract of vitamin B12 and folic acid is often impaired. The absorption of vitamin B12 is normalized by intake of dietary supplements containing calcium.

Lasix

What is Lasix?

Lasix is an oral drug indicated in all forms of edema of cardiac genesis, inadequate edema control (of renal or non-renal origin), corticosteroid refractory edema, light and medium hypertension.

Lasix 40mg in solution for infusion and in tablets of 500 mg is indicated only in cases of acute or chronic kidney failure, as well as in individuals with nephrotic syndrome (chronic glomerulonephritis, lupus erythematosus) and kidney insufficiency.

What is Lasix used for?

hypertension Lasix in forms of pills is taken by 1-3 tablets in a single dose, choosing the time depending on when you want to get the diuretic effect. The same lasix dosage can be used as a part of therapy appointed for high blood pressure.

In case of failure or insufficient effect it is possible to replicate the furosemide dose at least 4 hours after the first intake. Regarding Lasix vials and Lasix 500mg tablets, furosemide dosage for edema must be adjusted according to the needs and requirements of the patient.

How does Lasix work?

Lasix is absorbed very quickly from the gastro-intestinal tract, maintaining a high bioavailability, which is between 50% and 70%. In the circulatory stream, furosemide (the active ingredient of Lasix is strongly bound to albumin and other plasma proteins, and subsequently excreted mainly through the urine. The rapid diuretic action of Lasix is achieved thanks to the biological effect of furosemide, the molecule in capable of acting at the level of the ascending tract of the loop of Henle and of the distal tubule (portions of the nephron – functional unit of the kidney responsible for the phenomenon of filtration / resorption) inhibiting resorption, mainly of chlorine and sodium, and further reducing the reabsorption of water in the proximal renal tubule.

Lasix Dosage

Adult patients with edema should begin their lasix treatment with 20 to 80 mg during the morning as a single dose. Initial heart failure treatment and hypertension treatment requires Lasix 40 mg as the standard dosage. For patients with kidney problems furosemide 40 mg dosage should be increased step by step until the desired effect is reached. Lasix 40 mg serves to treat fluid accumulation which occurs in congestive heart failure liver disease and kidney disorders.

Maximum daily dose of lasix should not exceed 600 mg because higher amounts lead to severe side effects including dehydration and electrolyte imbalances. Your doctor will determine your specific dosage through monitoring your body’s response and kidney function.

How long does Lasix stay in your system?

After oral administration, furosemide effect occurs within 1 hour, reaches its peak after 1-2 hours and lasts between 6 and 8 hours.

Lasix Side Effects

The side effects associated with the administration of Lasix can also be achieved at therapeutic doses and include:

Increased urinary electrolyte excretion, resulting in increased thirst, headache, confusion, muscle cramps, tetany, myasthenia, cardiac rhythm changes and gastro-intestinal disorders. These conditions are also closely associated with the concomitant presence of pathologies of various kinds and unbalanced nutrition.
Dehydration, more frequent in elderly patients, with possible thrombosis linked to haemoconcentration and consequent increase in serum levels of creatinine, uric acid, triglycerides and cholesterol.
Reduced glucose tolerance, with potential worsening of glycemic control in patients with diabetes mellitus.
Hypotension with consequent state of confusion, headache, dizziness, drowsiness, visual disturbances, weakness, dry mouth and difficulty maintaining an upright position.
Skin reactions, rash, erythema, dermatitis and shock (very rare), in case of hypersensitivity to the drug or to one of its components.
In the event of an overdose, the onset of the aforementioned side effects is more likely and significantly faster.

Lasix is salable only under medical prescription. Lasix should always be used after consulting your doctor.

Lasix Precautions

haemoconcentration Before taking the drug Lasix during the therapy, it is necessary to make sure of the urinary tract patency, the levels of potassium, sodium, creatininemia, glycaemia, glycosuria, acid-base are in good balance. More careful monitoring, and strict supervision by medical personnel, are required in the treatment of patients with hypotension, diabetes mellitus, gout, hepatoneural syndrome, liver disease, nephrotic syndrome etc.

Although therapy with Lasix has been associated with hypokalaemia only in very rare cases, before and during treatment it would be necessary to add potassium-rich foods, such as potatoes, bananas, oranges, tomatoes and spinach to your diet.

The potential and unpredictable hypotensive action of Lasix could compromise the patient’s perceptive and reactive abilities, and negatively influence the ability to use vehicles and machinery.

Lasix should not be administered during the entire pregnancy period.

The active ingredient of Lasix can easily pass into breast milk and inhibit lactation, as well as creating damage to the newborn; therefore it would be appropriate to suspend breast-feeding during therapy with furosemide.

Lasix Contraindications

Lasix should not be used in the event of:

Hypersensitivity to one of its components;
Sulfonamide allergy for possible cross-reactivity with furosemide;
Severe hypotension;
Hypokalemia, hyponatremia;
Hepatic encephalopathy;
Coma or precoma;
Pregnancy, even presumed, and breastfeeding.

The state of gastric filling and the concomitant administration of food can reduce the absorption profile of Lasix altering its normal functionality; therefore we recommend taking this drug on an empty stomach.

Lasix can also interact with different drugs:

Sucralfate, with consequent reduction in the absorption of furosemide (it is therefore recommended to administer it after at least 2 hours).
Lithium salts, reducing the elimination of this compound, with a consequent strengthening of the toxic effects.
ACE inhibitors, with possible severe hypotension and serious impairment of renal function.
Non-steroidal anti-inflammatories, with reduction of the biological efficacy of furosemide.
Corticosteroids, high-dose licorice, carbenoxolone resulting in hypokalemia.
Antihypertensives of various kinds, with possible pressure drop
Chloral hydrate, with skin redness, sweating, agitation, nausea and tachycardia.
Antidiabetic drugs, increasing their elimination in the kidneys and reducing their therapeutic power.

Generic Lasix Names

Diucontin-K – Modi Mundipharma Ltd.
Frusenex – Geno Pharmaceuticals Ltd
Frusenex – Geno Pharmaceuticals Ltd
Frusix – Cipla Limited
Fursimide – Alixinox Pharmaceuticals

Yasmin

What is Yasmin?

Yasmin drug is a contraceptive pill and is used to prevent pregnancy. Each tablet contains a small amount of two female hormones, drospirenone and ethinylestradiol. Contraceptive pills that contain two hormones are called combination pills.

What are Yasmin pills for?

The main purpose of Yasmin tablets is birth control but doctors also use them to treat acne and manage menstrual cycles.

Is Yasmin a Combined Pill?

The medication functions as birth control because it contains ethinylestradiol estrogen and drospirenone progestin when taken properly.

What is Yasmin Pill Used For Beyond Contraception?

The medication helps women with hormonal imbalances to achieve regular periods while also reducing premenstrual symptoms.

How Many Pills in Yasmin Pack?

The pack contains 21 active hormone tablets which are followed by a 7-day break that results in menstruation.

Mechanism of action

Yasmin pills prevents the maturation of the egg cell creating a situation similar to that of pregnancy (without an egg cell, neither fertilization nor pregnancy is possible). Moreover, the pill creates a thickening, at the entrance of the uterus, of the cervical mucus, so the spermatozoa in any case do not rise up to the fallopian tubes, where fertilization takes place.

Yasmin pill ingredients contains estrogen and a synthetic progestin: they are similar to natural ovarian hormones, estradiol and progesterone which, as a result of taking the pill, are “asleep”. The mechanism of action of contraceptives with predominantly progestin content arises from the combination of ovulation block with other effects.

Yasmin Pill Instructions

Take one Yasmin tablet every day, if necessary with a little water. The pills can be taken on an empty stomach or after a meal, but you should take them at about the same time each day.

There are 21 pills in Yasmin blister. Days of the week are marked next to each pill. Start taking the pills from the slot with the corresponding week day marking: Mon for Monday, Tue for Tuesday, etc. Always take Yasmin pill at the same time of the day.

Do not take tablets for 7 days. During these 7 days (so-called week of suspension) menstruation must appear. This is called “suspension bleeding” and generally begins on the second or third day of the week of suspension.

On day 8, commence a new blister of Yasmin (ie after the 7-day break), regardless of whether or not menstruation ends. This means that every new birth control Yasmin medication blister has to start on the same day of the week and menstruation will also start every month on the same day.

If you follow the instructions above, Yasmin contraceptive effect will be preserved even during the 7 days of suspension menstruation.

Yasmin Directions

birth-control-pills Yasmin pill must be taken every day at the same time and, even if there is a certain hourly tolerance, at least the band must be respected; example: if it is lunch time, the next day cannot be at dinner time nor the third day at breakfast time.

If during a regular intake one realizes that one has missed to take a pill, if more than twelve hours have passed since the time of the missed intake, it is possible to take the missed Yasmin dose and the contraceptive effect is guaranteed.

Yasmin vs Ocella

Ocella is a different brand name for the same medication; the drugs are mutually interchangeable.

Yasmin vs Marvelon

Like Yasmin birth control pill, Marvelon is a combined contraceptive pill to be taken by mouth. Each tablet contains a small amount of two different female hormones. These are desogestrel (progestin) and ethinylestradiol (estrogen). In view of the low hormone content, Marvelon is considered a low dose oral contraceptive. Since all the tablets in the pack contain the same hormones in the same dose, Marvelon is considered a combined monophasic oral contraceptive.

Yasmin vs Lucette

Lucette has identical composition with Yasmin contraceptive pill, which is drospirenone and ethinylestradiol used in the same proportions as in Yasmin: 0,03mg / 3mg. Lucette is manufactured by Consilient Health Ltd.

Yasmine vs Alesse

Alesse is a birth control pill based on levonorgestrel (progesterone) and ethinyl estrad (estrogen), which makes it a classical combination contraceptive pill with effects similar to those of Yasmin contraception. Your prescriber might decide in favor of one drug over the other in case of individual intolerance to drugs’ composition or adverse event incidence.

Yasmin vs Levlen

Levlen is a contraceptive used orally. The birth control effect is achieved thanks to the two components, the hormones ethinylestradiol and levonorgestrel. Ethinylestradiol can be found in the composition of Yasmin birth control pills. The choice between the two drugs should be carried out by a healthcare provider.

Yasmin vs Dianette

generation-hormonal-combination-drug Dianette is a combination hormonal pill composed of cyproterone acetate and ethinylestradiol, thus having one of its ingredients in common with Yasmin bith control. The use of Dianette is reserved for cases in which the treatment of androgen-dependent pathologies is necessary. Although due to its composition Diane also has a contraceptive effect, it should not be used for this purpose. Therefore after the complete resolution of the conditions for which the medicine has been prescribed it is recommended not to use further Dianette for contraceptive purposes only.

Yasmin Side effects

Side effects of Yasmin include both mild and serious reactions that require medical attention, tend to occur during the initial months of use but usually disappear as your body adapts to the hormonal changes. Rare cases of blood clots can occur with Yasmin contraceptive pill side effects starts with chest pain and severe headaches and swelling in the legs. Women who smoke or have high blood pressure need to consult their doctor about their increased risk of severe yasmin pill side effects before beginning treatment.

Mastalgia associated with increased breast size;
Acne;
Increased body weight;
Headache and migraine;
Nausea and vomiting;
Mood swings;
Changes in libido;
Irregularity of the menstrual cycle, absent or light periods and intermenstrual blood loss (spotting);
Abdominal cramps.

Precautions

The following risks should be considered when taking Yasmin contraceptive pill :

The risk of ovarian cyst formation. Ovarian cysts are not dangerous and tend to resolve spontaneously; however, in some women, they can be painful (pelvic pain);
The risk of increased susceptibility to breast cancer and cervical cancer.

Contraindications

The following represent a contraindication to the use of the Yasmin:

Simultaneous use of certain drugs, such as rifampicin and rifabutin antibiotics, carbamazepine antiepileptic drugs, oxcarbazepine, phenytoin and phenobarbital, hypericum and some antiretroviral medicines used to treat AIDS. These preparations reduce the effect of Yasmin.
The presence of a cardiovascular disease;
The presence of a liver disease;
A past history of breast cancer and family predisposition to this tumor;
A past history of continuous ovarian cysts.

Ventolin

Ventolin is a drug based on the active ingredient salbutamol, belonging to the respiratory adrenergic category and specifically selective beta2-adrenergic receptor agonists. Ventolin is used for the treatment of various diseases and pathologies such as asthma, emphysema and sinusitis.

Action: how Ventolin works

Salbutamol-100-mcg Salbutamol is a short-acting selective β2 receptor agonist. β2 receptors are predominant in bronchial smooth muscle. Selectively bound to β2-adrenergic receptors in bronchial smooth muscle, salbutamol activates the intracellular adenylate cyclase, an enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic adenosine monophosphate (cAMP)

The increase in cAMP determines:

Bronchodilation: in fact cAMP catalyzes the activation of kinase proteins that determine the inhibition of the release of calcium ions from intracellular deposits, the sequestration of intracellular Ca2 + and a reduction in the entry of Ca2 +, with consequent relaxation of smooth muscle and therefore bronchodilation
Inhibition of the release of phlogogenic mediators from mast cells
Increased mucociliary clearance

What is Ventolin used for?

Ventolin is indicated for the treatment of bronchial asthma and obstructive bronchopathy with asthmatic component. Ventolin 100 mcg pressurized inhalation suspension is indicated in adults, adolescents and children aged 4 to 11 years.

Ventolin contains salbutamol, a substance which is a selective beta2 adrenergic agonist administered in bronchospasm therapy. Ventolin provides short duration bronchodilation (4 hours) in reversible airway obstruction caused by asthma, chronic bronchitis and emphysema.

Use & dosage

Ventolin should only be administered by inhalation. An increased need to use beta2-agonists may indicate a deterioration in asthma conditions. If this occurs, a review of the patient’s treatment plan may be considered. Suitable spacer devices can be applied. Since adverse events may occur at high doses, the dosage and posology are a subject to change upon the doctor’s advice. The duration of Ventolin action most patients is 4–6 hours. Adults Treatment of acute bronchospasm and control of episodic asthma 1–2 inhalations (100–200 mcg).

Chronic therapy

Up to 2 inhalations (200 mcg) 4 times a day. The use of Ventolin should not exceed 4 administrations per day. Perform a maximum of 2 spray administrations at a time and do not repeat the treatment before 4 hours. The increase in the rate of the administration and the dosage of symptoms of the sudden worsening of asthma conditions.

Pediatric population

Children using Ventolin 100 mcg pressurized inhalation suspension may benefit from the special spacer with a facial mask.

Attenuation of bronchospasm in the acute phase

Habitual Ventolin dose for children under 12 years: 1 inhalation (100 mcg). The dose can be increased up to 2 inhalations (200 mcg), if necessary.

Pediatric population of 12 years of age and older: the same Ventolin doses as in adults are applied. Use of Ventolin pressurized inhalation suspension should not exceed 4 doses per day. The need to take additional doses or increase the dose indicates a deterioration in asthma condition.

Chronic therapy

Habitual dosage for pediatric population under 12 years: up to 2 inhalations (200 mcg) 4 times a day. Pediatric population 12 years of age and older: adult Ventolin dosing rules apply.

Interactions with other medicines

Normally Ventolin and non-selective beta-blockers, such as propranolol, should not be prescribed simultaneously. Ventolin is not contraindicated in patients receiving monoamine oxidase inhibitors (anti-MAO drugs); patients on tricyclic antidepressants and digoxin may present the risk of greater cardiovascular effects. Severe hypokalaemia may follow coadministration with xanthine derivatives, steroids, diuretics and beta2-agonists.

While you are using Ventolin

A sudden aggravation of the symptoms may require an increase in the dosage of steroids that must be administered urgently under the supervision of the doctor. In patients considered at risk, daily monitoring of the peak flow can be recommended by the doctor. You should consult your doctor whenever the usual efficacy or duration of action is decreased and you do not increase the dose or frequency of administration. Sympathomimetic agents should be used very cautiously in patients who may be particularly susceptible to their effects. Tell your doctor if you have heart disease or angina before starting salbutamol therapy.

In patients with diseases such as coronary heart disease, arrhythmias, arterial hypertension and in patients with glaucoma, hyperthyroidism, thyrotoxicosis, pheochromocytoma, diabetes and prostatic hypertrophy, the product should be used only in cases of absolute necessity.

Ventolin for asthma treatment

therapy-in-asthma Patients with severe asthma have constant symptoms and frequent exacerbations; their lung function is reduced, they have PEF values lower than 60% of normal with variability even higher than 30%.

The treatment of asthma should normally be performed as part of a therapeutic plan adapted to the severity of the disease; the patient’s response to therapy must be verified both clinically and via pulmonary function tests.

The need to resort more frequently to inhaled beta2-agonists with a short duration of action for the control of symptoms, indicates a worsening of asthma control; in this circumstance the treatment plan must be modified.

A sudden and progressive aggravation of asthma is potentially life-threatening and may call for establishing corticosteroid therapy or increasing its dosage.

Chronic bronchitis

Both bronchitis and asthma are two very common lung conditions. Each has its own characteristics:

Origin: infectious for bronchitis; often allergic to asthma.

Physiology: secretion of pus for bronchitis; narrowing of the bronchi for asthma. In this type of bronchitis, the mechanisms are multiple: intensity of the initial inflammation that causes the constriction of bronchi too reactive, or a lot of edema in the wall, or excess secretions that obstruct airways.

Symptoms: fever, cough and sputum for bronchitis; difficulty breathing for asthma.

In this connection, it is logical to use Ventolin in chronic bronchitis alongside with other therapies as indicated by prescriber; often antibiotics for this type of bronchitis are added.

Contraindications

Ventolin is contraindicated in case of sensitivity to the active ingredient or to any of the complementary substances. Salbutamol formulations should not be used in the threat of abortion.

Although a percentage of congenital anomalies similar to that reported in the population not exposed to the drug was reported among the patients who took salbutamol during pregnancy, its use in pregnancy is not recommended, except in cases where the benefit to the mother is greater than the possible risk to the fetus.

Side effects

In addition to the beneficial effects, each drug can have some side effects. Unlike corticosteroids taken by mouth or by injection, inhaling this drug does not cause serious health risks. In addition to dry throat and hoarseness, inhalation may rarely cause coughing or, paradoxically, breathing difficulties. The only disorder that occurs with some frequency is candidiasis of the mouth (or lily of the valley), a fungus infection easily recognizable by its white color. To reduce the risk of candidiasis it is important to rinse the mouth with water after inhalation, to remove the share of the drug deposited in the mouth.

Aciclovir

What is Aciclovir?

herpes-virus

It is a drug that can kill the viruses responsible for some infections called “herpes” generically. It does not cure the infection definitively but reduces the time needed for the body to control it and shortens the time for healing of the lesions. The drug does not prevent the transmission of the virus to other people and does not serve against other common viral diseases such as the flu or the cold: it is active only in “herpes virus” infections.

The use of Aciclovir is indicated for:

Treatment of Herpes zoster virus (HSV) infections in adults;
Prevention and treatment of recurrent HSV eye infections in adults and adolescents over 12 years of age;
Prevention and treatment of skin infections due to Herpes simplex virus (HSV) and treatment of genital herpes in adults and adolescents over 12 years of age;
Treatment of cold sores;
Prevention of Cytomegalovirus (CMV) infections after organ transplants in adults and adolescents over 12 years of age.

Aciclovir – Mechanism of Action

Aciclovir is a structural analogue of the guanosine nucleotide. It is phosphorylated in vivo only in cells infected by the virus, which codes for the enzyme thymidine kinase, which, in fact, is the enzyme that catalyzes the phosphorylation of acyclovir.

In this way the selectivity of the action of the drug on the infected cells is obtained, without it acting at the level of healthy cells.

Acyclovir is further phosphorylated to form acyclovir triphosphate. The latter binds and inhibits the viral DNA polymerase (a key enzyme for the replication of the virus within the cell). In particular, it acts as a competitive inhibitor of viral polymerase, preventing the binding of deoxyguanosine triphosphate, with which it shows structural similarity. Acyclovir is incorporated into the newly formed DNA strand and causes an error in the DNA replication process, preventing further replication of the virus in the cells of the host organism.

Aciclovir Uses and Dosage

Aciclovir Tablets

The drug should be taken by mouth during meals, usually 5 times a day, with a distance of 4 hours between one administration and another, or according to the doctor’s prescription. The drug should generally be continued for 5-7 days, unless otherwise prescribed by the doctor, based on the disease to be treated or prevented. If you miss a dose, take it as soon as possible and take the next dose according to the schedule indicated by your doctor.

Aciclovir Vials

Inject, after appropriate dissolution of the powder, only by slow venous infusion (at least an hour), carried out by authorized health personnel. Do not inject intramuscularly or subcutaneously.

The reconstituted solution should be used immediately after preparation.

Aciclovir CreamThe drug should be applied to the affected area, at the onset of the first signs (redness, sensation of “discomfort”), 5 times a day (every 4 hours), until the symptoms disappear (5-10 days).

Aciclovir Directions

Store Aciclovir at room temperature, in a cool place (under 25 C) and dry and away from light. Do not use the drug if the label indicates that it has expired. Keep it away from children. Store the medicine in the original package together with the package insert.

Aciclovir vs Valaciclovir

Valaciclovir is a prodrug, which means that – before carrying out its antiviral action – valaciclovir must be converted through hepatic metabolism into its active metabolite which is acyclovir.

Valaciclovir is more absorbed at the gastrointestinal level than its active metabolite acyclovir. Therefore, the oral administration of valaciclovir allows to reach higher plasma concentrations of acyclovir than those that could be obtained by administering acyclovir as such.

Aciclovir vs Penciclovir

Penciclovir is an active ingredient with extensive antiviral activity, particularly effective against Herpes Simplex Virus. Applied to the area affected by the infectious process, Penciclovir easily permeates the membranes of infected cells, being phosphorylated to Penciclovir triphosphate first by specific viral enzymes and then by cell kinases.

The antiherpetic activity of Penciclovir is inferior to that of Aciclovir, the difference in the drugs’ effectiveness which is especially pronounced in patients with immune deficiency. This is explained by Penciclovir weaker ability to inhibit the DNA essential in Herpes virus replication, polymerase. Penciclovir, however, has proven efficacy against HSV-2. Laboratory tests should be carried out before your prescriber approves for application of either of the drugs, but Aciclovir features a broader spectrum of actions.

Aciclovir vs Abreva

Abreva (doconasol) is an OTC drug administered in labial herpes patients. Abreva is unique in the meaning that it is the only non-prescription antiviral drug used for the treatment of this condition alongside with other similar medications. Abreva is available in form of cream and oral tablets.

Abreva, unlike Aciclovir, is a non-prescription drug. Its efficacy is less intense, and it has a milder effect compared to Aciclovir. Abreva can be used in initial stages of the disease, but is not recommended to be used if the disease has become chronic.

Aciclovir vs Doconasol

Doconasol is the nonproprietary name for Abreva, the OTC drug described above. Compared to Aciclovir, it produces a milder action and is available without prescription in form of topically applied cream or oral tablets.

The recommendations described for Abreva apply: Doconasol should be used as a therapy in milder forms of the viral infection.

Aciclovir vs Ganciclovir

herpes-zoster-virus Ganciclovir is an antiviral drug capable of interfering with DNA replication of viruses. From the chemical point of view, ganciclovir is an analogue of deoxyguanosine, one of the nucleosides that makes up DNA. Ganciclovir is marketed as pharmaceutical formulations suitable for ocular and intravenous administration.

The use of Ganciclovir is indicated for:

Treatment and prevention of infections caused by cytomegalovirus in patients with impaired immune defenses (intravenous administration);
Prevention of cytomegalovirus infections following organ transplants (intravenous administration);
Treatment of superficial eye infections caused by viruses (ocular administration).

The drugs have similar effects and mechanisms, which makes them interchangeable. In studies, both drugs have shown the same efficacy, but Aciclovir was reported to have fewer side effects.

Aciclovir Side Effects

They are rare but nausea, vomiting, diarrhea, headache, feeling of drunkenness, confusion, agitation, tremors, rash, hives, itching and fatigue have been reported as side effects of Aciclovir.

Aciclovir Precautions

Concomitant administration of oral or intravenous acyclovir and cimetidine (a drug used to reduce acid secretion of the stomach) or probenecid (a drug used to treat gout) may decrease the elimination rate of aciclovir and increase it accordingly , plasma concentration.

In any case – regardless of the type of pharmaceutical formulation based on acyclovir that is used – it is always good to inform your doctor if you are taking, or have recently been, any type of medication, including medicines without a prescription. and herbal and / or homeopathic products.

In elderly and renally impaired patients, a reduction in the dose of aciclovir usually administered orally and intravenously may be necessary.
In addition, elderly patients and patients with renal insufficiency are exposed to a greater risk of occurrence of side effects affecting the central nervous system, in which connection, they must be constantly monitored.
Patients receiving high-dose oral aciclovir should drink sufficient amount of water to maintain hydration.
Aciclovir can trigger the onset of adverse events that can affect the ability to drive and / or use machinery, so care should be taken.
If you suffer from genital herpes, a condom should be used during sexual intercourse to prevent the transmission of the virus to your partner.

Aciclovir Contraindications

It will be necessary to carefully check the composition of the aciclovir-based drug that you will take because it is the composition of the latter that will determine possible contraindications. Regarding the active ingredient alone, any allergy to Aciclovir is a contraindication, and any liver problems or dehydration should be reported to your doctor to adapt the treatment accordingly.

Zovirax

What is Zovirax?

Zovirax drug (acyclovir, or aciclovir) is an oral drug used in treatment of viral infections with Herpes simplex and varicella zoster. The drug is also available in form of 5% cream (ointment) for topical application).

Zovirax Uses

viral-infections The formulations by mouth include a zovirax dosage of 200-400 mg (up to zovirax 800mg dosage in the case of genital herpes) for 5 times a day for at least 5 days. The dose should be halved in children under 2 years old. For the attenuation of varicella zoster in adults the usual posology is zovirax tablets 200mg dosage for 5 times a day for 7 days; in children, zovirax tab is defined by the doctor based on weight and age. The cream formulations, indicated for primary or recurrent cold sores and genital infections, should be applied 5 times a day, for a period of 5-10 days.

Note: Herpes simplex infections of the mucous membranes of the mouth and vaginal discharge require treatment by mouth.

How Does Zovirax work?

Aciclovir (Zovirax) works by blocking the DNA synthesis of the virus, preventing cell replication without interfering with the duplication of human DNA.

How Long Does Zovirax Stay in Your system?

The bioavailability of orally administered Zovirax is estimated between 15% and 30%. The drug is eliminated through kidneys after 1.5-2 hours. This period of time is extended to 19.5 hours in patients with kidney failure.

Zovirax Side Effects

Zovirax 400mg can cause various types of side effects, although not all people experience them. This depends on the different sensitivity that each individual has towards the drug. Therefore, it is said that the undesirable effects do not all occur with the same intensity in each patient. The main side effects that can occur during Zovirax treatment are listed below.

Zovirax medication is an effective and very well tolerated antiviral drug. Zovirax oral therapies may be associated with modest side effects:

nausea
abdominal pain
fatigue
headache
rash
itching

Aciclovir zovirax cream can cause a slight sensation of itching or itching in the application point especially the first 2-3 days.

Zovirax Contraindications

Oral Zovirax tablets are not contraindicated during pregnancy or during breastfeeding, but the opportunity of their use should be evaluated by the doctor.

Aciclovir Generic Names

Accrivir – Sivling Technologies Pvt. Ltd.
Aciherpin – Agio Pharmaceuticals Ltd.
Acirax – Synmedic Laboratories
Acivir DT – Cipla Limited
Acv – Geo Pharma Pvt. Ltd.
Acvirall Dis – Terrace Pharmaceuticals Pvt. Ltd.
Acyclovir – Chandra Bhagat Pharma Pvt. Ltd.
Axovir – Samarth Pharma Pvt. Ltd.
Civir DT – Biomax Biotechnics Pvt Ltd
Clovirax DT – Maneesh Pharmaceuticals Ltd
Cyclopiz – Gary Pharmaceuticals P Ltd.
Docvir DT – Swiss Pharma Pvt. Ltd.
Herperax – Micro Labs Ltd (Gratia)
Herpex – Torrent Pharmaceuticals Ltd.
Herzovir – Chandra Bhagat Pharma Pvt. Ltd.
Lyrovir – Lyra Laboratories Pvt Ltd
Ocurax – IPCA Laboratories Ltd. (Innova)
Optiviral – Entod Pharmaceuticals Ltd.
Virclo – Shinto Organics (P) Ltd.
Virex – BDH Industries Ltd.
Zovir – East West Pharma
Zoylex – Neon Laboratories Limited

Where to Buy Zovirax Online

You can order Zovirax without prescription online. This will not only save your time and efforts, but will also be a more economical solution; online pharmacies charges considerably less money for the products they distribute, since they skip so many expenses that brick-and-mortar pharmacies face.

Zovirax for shingles is a prescription drug and is not devoid of a certain number of contraindications (see Contraindications section), therefore professional healthcare consultation should be made, at your local health center or online, before you proceed with acyclovir therapy.

Prednisolone

What is Prednisolone?

Prednisolone is a corticosteroid drug used in the treatment of patients with moderate to severe rheumatoid arthritis (RA). The rationale for the use of corticosteroids in RA is the rapid control of symptoms during the phases of exacerbation of the disease mediated by the anti-inflammatory effect.

arthritis

In addition to simple symptomatic improvement, corticosteroids have been shown to slow down the rate of destruction of the joints at the same like the disease-modifying antimicrobial drugs (DMARD). In current treatment strategies for less aggressive forms of AR, corticosteroids are often associated with a DMARD (usually the methotrexate that is better tolerated). Systemic side effects, even at low doses, are the main limiting factor for their long-term use. Prednisone, at a dose of 7.5 mg a day, is able to maintain good control of symptoms (which at this dose lasts only 6-12 months) and to slow the progression of joint damage to a maximum of 2-4 years without problems, after which it must be gradually reduced and suspended.

Prednisone, administered in the form of an immediate-release oral preparation, is absorbed rapidly and almost completely; reaches maximum plasma concentrations after approximately 2 hours. More than 80% of prednisone is converted into the active metabolite prednisolone via hepatic first pass metabolism. After new hepatic metabolism, prednisolone is transformed into inactive metabolites that are mainly eliminated via the kidneys. The half-life of prednisolone is about 3 hours. The profile of plasma concentrations of prednisone MRI is very similar to that of immediate-release prednisone (at the same dose) with the difference of a time to reaching delayed peak levels of about 4 hours.

MRI prednisone tablets should be taken whole around 10pm, not in the morning as is currently the case with traditional preparations. If more than 2-3 hours have passed since the evening meal, the CPR recommends taking them after a snack (eg a slice of bread with ham or cheese); fasting may reduce bioavailability.

What is Prednisolone used for?

Prednisolone is mainly used in anti-inflammatory and antiallergic therapy, in case of asthma or inflammation (arthritis). They are also used for Addison’s disease (chronic adrenocortical insufficiency characterized by hyperpigmentation, sense of weakness, weight loss, in these subjects even trivial infectious or traumatic stimuli can lead to shock), for the prevention of rejection syndrome (after transplantation of ‘organ, due to their immunosuppressive effect) and in various types of blood and skin diseases.

Like all NSAIDs, corticosteroids can also cause damage to the gastric mucosa, both by direct action and by interference with the metabolism of arachidonic acid and by decreasing the number of prostaglandins, which have a mucoprotective effect.

Other undesirable effects are:

redistribution of body fat towards the face and neck and muscle thinning (Cushing’s syndrome)
osteoporosis
hyperglycemia (undesirable in diabetics) and decreased resistance to infections, which can lead to states such as oral candidiasis
increase in wound healing time
appearance or worsening of acne
hirsutism effects.

They may also have mineralocorticoid effects (sodium and water retention due to aldosterone receptors binding) and blood clotting effects.

What is the difference between Prednisone and Prednisolone?

Both Prednisone and Prednisolone belong to the same class of medications called synthetic corticosteroids and are used for the treatment of the same conditions, namely ulcerative colitis and other gastro-intestinal diseases of inflammatory nature, rheumatoid diseases, airway inflammations, such as bronchitis, asthma and associated problems, etc.

Prednisone and Prednisolone are interchangeable drugs, but according to this study, the levels of Prednisolone are cleared faster and in a safer way in patients with compromised liver function, therefore its use is preferable in individuals from this subcategory.

What are the side effects of Prednisolone?

In the 3-month comparison study , there were no differences between immediate-release prednisone and MR prednisone in safety profile, but a predefined list with standardized score was not used for recording adverse events as would have been necessary. In the open-label extension study, with a median duration of treatment of 281 days and a mean prednisone dose of 6.8 mg per day, the incidence of adverse events was 51% (including a 4.8 % drop out), similar to that of historical controls.

During the 12 months of observation required by the controlled study and by the open-label extension phase, the corticotropin release hormone (CRH) response test performed in three steps several (at the baseline, at the end of the 3 months in double blind and 9 months in the open) on a small group of patients (n = 28) did not find signs of suppression of the pituitary-adrenal axis.

Precautions

A single dose of cortisonic, even very high, is practically devoid of toxic effects, which occur with the chronicity of the use of the drug. The main problem that can lead to prolonged use of these drugs is adrenal insufficiency, which can also become fatal.

Contraindications

Prolonged therapy should be interrupted gradually; corticosteroids are contraindicated in cases of:

ulcer
diabetes
heart failure
osteoporosis
hypertension

Where can you buy Prednisolone online?

Prednisolone is a generic version of more expensive brand medications containing the same active component. Generic drugs are easily available online, but caution should be exercised when ordering healthcare products. Find a vendor with clearly formulated terms and conditions of use, as well as protected customer privacy and secure payment. A good online pharmacy makes buyer’s health its priority, so look for e-drugstores where healthcare services are included or offered as an option.

One can buy Prednisolone online and have it delivered to a specified address. This convenience does not exempt you from your responsibility as a patient: you need to be aware of existing contraindications and possible pharmacological interactions to avoid. Medical consultation is required under all circumstances.

What are other names for Prednisolone?

Aripride – Sarian Healthcare
Depotex – German Remedies (Aeroforce)
Emcort – Captab Biotec
Intralone – Intra Labs India Pvt. Ltd.
Lumi-M – Aronex Lifesciences Pvt. Ltd.
Macpred – Macleods Pharmaceuticals Ltd. (Macphar)
Nicort – AHPL
Paxopred – Pax Healthcare
Predace – Micro Labs Ltd (Gratia)
Predon-M – Orion Biotech Pvt. Ltd.
Predzest Tablet – Innovative Pharmaceuticals
Predzen Tablet – Ikon Remedies Pvt. Ltd.
Premisol – Molekule India Pvt. Ltd.
Zencort-M – Zenon Healthcare Ltd

Mobic

What is Mobic (meloxicam)?

Mobic medication contains a nonsteroidal anti-inflammatory drug (NSAID). Usually it is used to relieve osteoarthritis or for rheumatoid arthritis. Its effects can be felt within an hour. The drug is developed and produced by the pharmaceutical company Boehringer Ingelheim, but Mobic generic is also available under various names, including the name of its active substance, meloxicam. Meloxicam dosage is limited to two strengths: Mobic 7.5 mg and Mobic 15 mg

Mobic Uses

inflammation-and-pain Mobic tablet is used to relieve pain related to auto-immune diseases, inflammations of various kind and pain associated with it. Typically, this product is used once a day. Your pharmacist may have given you a different schedule that is more suitable for you. Depending on the condition being treated, it can be used regularly or only as needed. Follow the directions given to you by your doctor or pharmacist.

It is important to follow the dosage on the label. Do not use more or more often than indicated. This medication can be taken with or without food, regardless of meals or snacks.

Meloxicam Mechanism of Action

Meloxicam belongs to the class of NSAIDs, which means that it can be used for the symptomatic treatment of various ailments: first of all, as the name suggests, they have a strong anti-inflammatory effect, and therefore are useful for the treatment of arthritis symptoms chronic inflammatory and osteoarthritis; it also has analgesic action, especially useful as regards mild and moderate pain (caused, for example, by bruises, lackluster and neuralgia, headaches, toothache, etc.); finally, it can counteract feverish states, thanks to its antipyretic action.

The mechanism of inflammation proceeds through a chain of reactions triggered by the release of particular chemicals, which act as mediators in the body, that is, facilitators of molecular events.

Meloxicam derives from an organic acid. The chain of biochemical events triggered by meloxicam leads to the synthesis of prostanoids (a group of molecules that includes prostaglandins) and leukotrienes, ultimately responsible for:

Increased permeability of blood vessels, which causes liquids to leak to peripheral tissues and therefore edema;
Sharpening of the sensitivity of peripheral receptors to pain, due to the release of transmitters such as bradykinin;
Vasodilation in the affected tissues;
Release of cytokines and interferons, which causes changes in thermoregulation and therefore increases in body temperature (fever).

Mobic Dosage Information

Initial recommended Mobic dosage for adults with osteoarthritis or rheumatoid arthritis begins at 7.5 mg taken once daily. Your doctor will determine if you need a dose increase to 15 mg taken once daily based on your treatment response.

Patients with kidney problems need to take a lower dose of mobic which should not exceed 7.5 mg per day.

Elderly patients need to receive the smallest effective dose of medication for the briefest period needed to manage their symptoms.

You should never change your mobic dosage without first consulting with your healthcare provider.

How long does it take for Mobic to work?

You will experience the effects of Mobic between 2.5-9 hours following the intake of the drug; this is when the peak concentration of the medication in blood plasma is reached.

Mobic Side Effects

Mobic-mechanism-of-action Each person may react differently to a treatment. If you think this is the cause of a problem that is bothersome to you, whether or not it is mentioned here, discuss it with your doctor or pharmacist. They can help you determine if your treatment is actually the cause and, if necessary, help you manage the situation well.

In addition to its desired effects, this product can occasionally cause certain undesirable effects (side effects), in particular:

headaches;
diarrhea;
it can give digestion problems;
dizziness – make sure you stand up slowly;
it can increase blood pressure;
nausea or, rarely, vomiting;
it can make your skin more sensitive to UV rays (eg, sun, tanning booth) – avoid exposure to UV rays as much as you can.

In general, the safety of meloxicam treatment has been proved in a number of studies, so this medication is safe to take when approved by a healthcare provider.

Meloxicam interactions

This medication may interact with other medications or supplements, sometimes in significant ways. However, it is possible to prevent more than one by adjusting the dose of your medication or by changing the timing. Check with your pharmacist before using this product in combination with other medicines, vitamins, or natural products.

It is not recommended to combine this medication with another anti-inflammatory. Check carefully for ibuprofen (Advil, Motrin), naproxen (Aleve), or diclofenac (Voltaren Emulgel) on drug labels.

Meloxicam and alcohol (Mobic and alcohol)

side-effects-of-Mobic Mobic and alcohol are poorly compatible. Avoid taking alcohol or products containing it while you are using this medicine. There are several harmful interactions that can develop between meloxicam and alcohol:

this combination increases – in older people, but not only – the risk of damaging the mucous membrane of the stomach, thus developing gastrointestinal ulcers and bleeding;
increases the risk of prolonged bleeding, due to the inhibitory action that certain NSAIDs have on the functionality of blood cells;
increases the risk of harmful effects (which can cause serious health problems, even death) on liver function.

These risks are further enhanced by the fact Mobic can be taken concomitantly with other drugs: in this case, as a precaution it would be better to avoid all consumption of alcoholic beverages.

How long after taking Mobic can I take ibuprofen?

Since both drugs belong to the same class, you should wait for at least 4 hours following the intake of Mobic generic name before you take a drug containing ibuprofen. The same goes for the dosing limitations; if you have used up the recommended dose of your NSAID medication during 24 hours, you should not follow it up by another drug of this class on the same day. Discuss the optimal theapy with your doctor (the benefits to risks ratio of meloxicam vs. ibuprofen in your individual case).

How long does Mobic stay in your system?

Mobic half-life is 20 hours; after this period, the drug begins to get eliminated from the body. The substance is metabolized by liver.