What is Eriacta?
Eriacta is an oral drug belonging to the class of phosphodiesterase type 5 inhibitors (PDE5 inhibitors) used to treat the symptoms of erectile dysfunction (ED) in men. The drug is taken as needed, making it possible for a man to achieve a hard and stable erection sufficient for an intercourse that is found satisfactory by both partners.
Mechanism of action
The active substance of Eriacta is sildenafil citrate, the same active component that is found in Viagra. Sildenafil was discovered in early 90s for the treatment of pulmonary arterial hypertension (PAH) and was reported to have a restorative effect on erectile mechanism as an unexpected side event. A few years later, in 1998, FDA approved the use of sildenafil molecule as the first oral solution for the treatment of ED that revolutionized the world of pharmacology.
Sildenafil citrate makes it possible for the natural erectile algorithm to occur. As mentioned previously, sildenafil is an inhibitor of PDE5, an enzyme that catalyzes breakdown of cyclic guanosine monophosphate (cGMP) found in the corpora cavernosa of the penis. Those latter are the two cylindrically shaped bodies in the penis lodged alongside urethra and build up by porous tissue that is designed to absorb blood and retain it while erection lasts, to then release the blood, bringing penis back to its relaxed flaccid state with the help of PDE5 enzyme.
In men affected with ED, the poor balance between PDE5 and cGMP does not allow a sufficient erectile hardness to take place. Sildenafil taken approximately 1 hour before sexual activity stimulates the release of nitric oxide (NO), which in its turn inhibits PDE5 and thus promotes the release of cGMP, allowing smooth muscle relaxation and free blood circulation in the corpora cavernosa. After ejaculation, PDE5 secretion is triggered by hormones coming into play, and the penis returns to its relaxed state.
Eriacta contains 100mg of the principal ingredient sildenafil, which is considered to be one step from an average dose found effective in 80.1% of men in phase III trials. The recommended dose depends on ED severity (mild to full, based on International Index of Erectile Function scale, IIEF). It should be determined by healthcare practitioner prescribing the drug, taking into account such factors as:
- ED severity
- comorbid conditions, if any
- patient’s age
- patient’s response to initial dose
- side effects, if any
It is a widely used practice to break 1 tablet of Eriacta in 2, splitting the dose between two intakes made on separate days. This helps to a) minimize side events and b) save money on drug refills.
Although it is stated that the dose of Eriacta does not need to be adjusted in elderly patients (aged above 65), there are individual factors that your prescriber will need to take into account when deciding on the minimal effective dose.
If the initial dose of Eriacta is found to not yield desired results, your prescriber will consider stepping up the drug dose. You should not take more than 1 recommended dose of Eriacta during 24 hours without your prescriber’s approval.
Eriacta pills are taken by mouth. Wash down the tablet with a sufficient quantity of water. Do not crush the tablet in the mouth or chew it.
Eriacta is taken as needed, with at least 60 minutes allowed for the drug’s action onset, but it should not be taken later than 4 hours before the planned sexual activity.
In order to minimize the risk of side effects, Eriacta tablet can be taken after a light meal. A more substantial meal or the one that is high on fat content will inhibit and / or delay the action of the drug.
Do not take Eriacta with alcohol; the latter compromises both the drug’s efficiency and sexual performance of the taker.
Eriacta vs Viagra
Eriacta is a generic version of the brand drug Viagra. The two drugs are identical in their composition, health and side effects, the mechanism of action, onset and duration of action, and other pharmacokinetic and pharmacodynamic factors.
Viagra cost is significantly higher, in average estimated at $73.91 per unit throughout the pharmacy chains in the US. In contrast, the per-pill price of Eriacta is around $4.09. This price gap is habitual for brand and generic drugs, and can be explained by a number of facts related to the peculiarities of pharmaceutical market.
Eriacta vs Kamagra
Both Eriacta and Kamagra are generic drugs containing sildenafil citrate found in the brand pill Viagra. They are produced by different pharmaceutical companies which are both based in India. Eriacta is manufactured by Ranbaxy Laboratories Ltd., while Kamagra is produced by Ajanta Pharma Ltd. Both companies have been active players of the pharmaceutical market place for decades and have been accredited for manufacturing sildenafil generics in their country of origin.
As far as the price differences between Eriacta and Kamagra are concerned, the price for Kamagra 100mg, a dose analogous to that of Eriacta, is $2.14.
Caverta vs Eriacta
Caverta and Eriacta are two full analogs produced by the same pharmaceutical company Ranbaxy Laboratories Ltd based in India. The pills are priced within a very close range, with minor excursions in cost depending on the retailer.
All medicines can cause side effects; they vary according the dosage and the patient’s individual response. Among the main notable side effects of Eriacta there are:
- Redness and heat in the neck and face (flushing)
- Clogged nose (nasal congestion)
- Muscle pain (body aches)
- Gastric reflux
- The risk of priapism (erection lasting more than 4 hours) has been noted, but remains very exceptional.
The absolute contraindication is the combination: Eriacta + nitrated drugs (NO donors, nitric oxide), such as trinitrin. Taking these two drugs concomitantly can result in collapse and have fatal consequences.
Nitrate medications are very often used to treat angina pectoris and cardiac disorders such as myocardial infarction. If you are in this situation, and you plan to take Eriacta, check with your cardiologist beforehand that the treatment you are taking does not contain nitrates. Cardiologists are accustomed to responding to this increasing demand and they have substitution treatments compatible with Eriacta.
It should be known that this formal contraindication also concerns poppers. These small bottles of vasodilator fluid found in sex shops also contain nitrates. Although banned for sale in France, they are still found on the internet. Potentially dangerous in themselves, their use with drugs containing sildenafil presents a risk of increased blood pressure collapse.
Patients with a recent cardiovascular history (stroke, heart attack, unstable angina) and / or who are not recommended for moderate physical exertion should seek the advice of their cardiologist before resuming sexual activity, regardless of this type of medication. To make love is indeed considered as an effort corresponding to the rise of 2 floors. If you are concerned, ask your doctor clearly.
And for all major pathologies (kidney failure, liver damage, cancer, retinal damage, etc.), you should seek the advice of your specialist before taking an erection facilitator. In order to determine whether or not it is compatible with your current treatment and your condition.
Do not take Eriacta in presence of cardiovascular contraindications: myocardial infarction or recent stroke (less than 6 months).
Eriacta is contraindicated in case of serious ophthalmic problems (non-arteritic anterior ischemic optic neuropathy).
The combination with certain treatments may lead to a change in maximal plasma concentration of sildenafil in blood, or even a transitional or definitive contraindication.
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